Cargando…
Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens
Many of the currently available anti-parasitic and anti-fungal frontline drugs have severe limitations, including adverse side effects, complex administration, and increasing occurrence of resistance. The discovery and development of new therapeutic agents is a costly and lengthy process. Therefore,...
Autores principales: | Arbon, Dominik, Ženíšková, Kateřina, Šubrtová, Karolína, Mach, Jan, Štursa, Jan, Machado, Marta, Zahedifard, Farnaz, Leštinová, Tereza, Hierro-Yap, Carolina, Neuzil, Jiri, Volf, Petr, Ganter, Markus, Zoltner, Martin, Zíková, Alena, Werner, Lukáš, Sutak, Robert |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380531/ https://www.ncbi.nlm.nih.gov/pubmed/35856666 http://dx.doi.org/10.1128/aac.00727-22 |
Ejemplares similares
-
Adaptive iron utilization compensates for the lack of an inducible uptake system in Naegleria fowleri and represents a potential target for therapeutic intervention
por: Arbon, Dominik, et al.
Publicado: (2020) -
MitoTam-01 Trial: Mitochondrial Targeting as Plausible Approach to Cancer Therapy. Comment on Yap et al. Complex I Inhibitor of Oxidative Phosphorylation in Advanced Solid Tumors and Acute Myeloid Leukemia: Phase I Trials. Nat. Med. 2023, 29, 115–126
por: Neuzil, Jiri, et al.
Publicado: (2023) -
Copper detoxification machinery of the brain-eating amoeba Naegleria fowleri involves copper-translocating ATPase and the antioxidant system
por: Grechnikova, Maria, et al.
Publicado: (2020) -
Copper Metabolism in Naegleria gruberi and Its Deadly Relative Naegleria fowleri
por: Ženíšková, Kateřina, et al.
Publicado: (2022) -
Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction
por: Sülzen, Hagen, et al.
Publicado: (2023)