Evidence of SARS-CoV-2 spike protein on retrieved thrombi from COVID-19 patients

The pathophysiology of COVID-19-associated coagulopathy is complex and not fully understood. SARS-CoV-2 spike protein (SP) may activate platelets and interact with fibrin(ogen). We aimed to investigate whether isolated SP can be present in clots retrieved in COVID-19 patients with acute ischemic str...

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Detalles Bibliográficos
Autores principales: De Michele, Manuela, d’Amati, Giulia, Leopizzi, Martina, Iacobucci, Marta, Berto, Irene, Lorenzano, Svetlana, Mazzuti, Laura, Turriziani, Ombretta, Schiavo, Oscar G., Toni, Danilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380658/
https://www.ncbi.nlm.nih.gov/pubmed/35974404
http://dx.doi.org/10.1186/s13045-022-01329-w
Descripción
Sumario:The pathophysiology of COVID-19-associated coagulopathy is complex and not fully understood. SARS-CoV-2 spike protein (SP) may activate platelets and interact with fibrin(ogen). We aimed to investigate whether isolated SP can be present in clots retrieved in COVID-19 patients with acute ischemic stroke (by mechanical thrombectomy) and myocardial infarction. In this pilot study, we could detect SP, but not nucleocapsid protein, on platelets of COVID-19 patients’ thrombi. In addition, in all three COVID-19 thrombi analyzed for molecular biology, no SARS-CoV-2 RNA could be detected by real-time polymerase chain reaction. These data could support the hypothesis that free SP, besides the whole virus, may be the trigger of platelet activation and clot formation in COVID-19. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13045-022-01329-w.

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