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Tissue specificity drives protective immunity against Staphylococcus aureus infection
Infections caused by Staphylococcus aureus range from mild to severe and frequently recur. Emerging evidence suggests that the site and severity of infection drive the potency of elicited immune responses and susceptibility to recurrent infection. In this study, we used tractable mouse models of S....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380724/ https://www.ncbi.nlm.nih.gov/pubmed/35983063 http://dx.doi.org/10.3389/fimmu.2022.795792 |
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author | Beesetty, Pavani Si, Youhui Li, Zhaotao Yang, Ching Zhao, Fan Chong, Anita S. Montgomery, Christopher P. |
author_facet | Beesetty, Pavani Si, Youhui Li, Zhaotao Yang, Ching Zhao, Fan Chong, Anita S. Montgomery, Christopher P. |
author_sort | Beesetty, Pavani |
collection | PubMed |
description | Infections caused by Staphylococcus aureus range from mild to severe and frequently recur. Emerging evidence suggests that the site and severity of infection drive the potency of elicited immune responses and susceptibility to recurrent infection. In this study, we used tractable mouse models of S. aureus skin infection (SSTI) and pneumonia to determine the relative magnitude of elicited protective immunity. Surprisingly, despite both SSTI and pneumonia eliciting antibody and local effector T cell responses, only SSTI elicited protective antibody and memory T cell responses and subsequent protection against secondary SSTI and pneumonia. The failure of pneumonia to elicit protective immunity was attributed to an inability of S. aureus pneumonia to elicit toxin-specific antibodies that confer protection during secondary infection and was associated with a failure to expand antigen-specific memory T cells. Taken together, these findings emphasize the importance of understanding protective immunity in the context of the tissue-specificity. |
format | Online Article Text |
id | pubmed-9380724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93807242022-08-17 Tissue specificity drives protective immunity against Staphylococcus aureus infection Beesetty, Pavani Si, Youhui Li, Zhaotao Yang, Ching Zhao, Fan Chong, Anita S. Montgomery, Christopher P. Front Immunol Immunology Infections caused by Staphylococcus aureus range from mild to severe and frequently recur. Emerging evidence suggests that the site and severity of infection drive the potency of elicited immune responses and susceptibility to recurrent infection. In this study, we used tractable mouse models of S. aureus skin infection (SSTI) and pneumonia to determine the relative magnitude of elicited protective immunity. Surprisingly, despite both SSTI and pneumonia eliciting antibody and local effector T cell responses, only SSTI elicited protective antibody and memory T cell responses and subsequent protection against secondary SSTI and pneumonia. The failure of pneumonia to elicit protective immunity was attributed to an inability of S. aureus pneumonia to elicit toxin-specific antibodies that confer protection during secondary infection and was associated with a failure to expand antigen-specific memory T cells. Taken together, these findings emphasize the importance of understanding protective immunity in the context of the tissue-specificity. Frontiers Media S.A. 2022-08-02 /pmc/articles/PMC9380724/ /pubmed/35983063 http://dx.doi.org/10.3389/fimmu.2022.795792 Text en Copyright © 2022 Beesetty, Si, Li, Yang, Zhao, Chong and Montgomery https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Beesetty, Pavani Si, Youhui Li, Zhaotao Yang, Ching Zhao, Fan Chong, Anita S. Montgomery, Christopher P. Tissue specificity drives protective immunity against Staphylococcus aureus infection |
title | Tissue specificity drives protective immunity against Staphylococcus aureus infection |
title_full | Tissue specificity drives protective immunity against Staphylococcus aureus infection |
title_fullStr | Tissue specificity drives protective immunity against Staphylococcus aureus infection |
title_full_unstemmed | Tissue specificity drives protective immunity against Staphylococcus aureus infection |
title_short | Tissue specificity drives protective immunity against Staphylococcus aureus infection |
title_sort | tissue specificity drives protective immunity against staphylococcus aureus infection |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380724/ https://www.ncbi.nlm.nih.gov/pubmed/35983063 http://dx.doi.org/10.3389/fimmu.2022.795792 |
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