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Auxiliary Screening COVID-19 by Serology

BACKGROUND: The 2019 novel coronavirus (COVID-19) pandemic remains rampant in many countries/regions. Improving the positive detection rate of COVID-19 infection is an important measure for control and prevention of this pandemic. This meta-analysis aims to systematically summarize the current chara...

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Detalles Bibliográficos
Autores principales: Pan, Xiongfeng, Kaminga, Atipatsa C., Chen, Yuyao, Liu, Hongying, Wen, Shi Wu, Fang, Yingjing, Jia, Peng, Liu, Aizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380738/
https://www.ncbi.nlm.nih.gov/pubmed/35983367
http://dx.doi.org/10.3389/fpubh.2022.819841
Descripción
Sumario:BACKGROUND: The 2019 novel coronavirus (COVID-19) pandemic remains rampant in many countries/regions. Improving the positive detection rate of COVID-19 infection is an important measure for control and prevention of this pandemic. This meta-analysis aims to systematically summarize the current characteristics of the auxiliary screening methods by serology for COVID-19 infection in real world. METHODS: Web of Science, Cochrane Library, Embase, PubMed, CNKI, and Wangfang databases were searched for relevant articles published prior to May 1(st), 2022. Data on specificity, sensitivity, positive/negative likelihood ratio, area under curve (AUC), and diagnostic odds ratio (dOR) were calculated purposefully. RESULTS: Sixty-two studies were included with 35,775 participants in the meta-analysis. Among these studies, the pooled estimates for area under the summary receiver operator characteristic of IgG and IgM to predicting COVID-19 diagnosis were 0.974 and 0.928, respectively. The IgG dOR was 209.78 (95% CI: 106.12 to 414.67). The IgM dOR was 78.17 (95% CI: 36.76 to 166.25). CONCLUSION: Our findings support serum-specific antibody detection may be the main auxiliary screening methods for COVID-19 infection in real world.