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Single-cell multiomics analyses of spindle-transferred human embryos suggest a mostly normal embryonic development

Mitochondrial DNA (mtDNA) mutations are often associated with incurable diseases and lead to detectable pathogenic variants in 1 out of 200 babies. Uncoupling of the inheritance of mtDNA and the nuclear genome by spindle transfer (ST) can potentially prevent the transmission of mtDNA mutations from...

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Detalles Bibliográficos
Autores principales:	Qi, Shuyue, Wang, Wei, Xue, Xiaohui, Lu, Zhuo, Yan, Jia, Li, Yunfei, Zhang, Yu, Shu, Mingming, Song, Chunlan, Wang, Qihang, Chuai, Yunhai, Zhai, Xinyu, Han, Shujie, Tang, Fuchou, Shang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380953/ https://www.ncbi.nlm.nih.gov/pubmed/35972936 http://dx.doi.org/10.1371/journal.pbio.3001741

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