MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation

Stress-activated p38 kinases control a plethora of functions, and their dysregulation has been linked to the development of steatosis, obesity, immune disorders, and cancer. Therefore, they have been identified as potential targets for novel therapeutic strategies. There are four p38 family members...

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Detalles Bibliográficos
Autores principales: Romero-Becerra, Rafael, Mora, Alfonso, Manieri, Elisa, Nikolic, Ivana, Santamans, Ayelén Melina, Montalvo-Romeral, Valle, Cruz, Francisco Miguel, Rodríguez, Elena, León, Marta, Leiva-Vega, Luis, Sanz, Laura, Bondía, Víctor, Filgueiras-Rama, David, Jiménez-Borreguero, Luis Jesús, Jalife, José, Gonzalez-Teran, Barbara, Sabio, Guadalupe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381040/
https://www.ncbi.nlm.nih.gov/pubmed/35971771
http://dx.doi.org/10.7554/eLife.75250

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