ORAL CHRONIC GRAFT-VERSUS-HOST DISEASE IN A COVID-19 PATIENT: A CASE REPORT OF A RAPID AND PROGRESSIVE DISEASE

Chronic graft-versus-host disease (cGVHD) is a common complication in patients undergoing haploidentical hematopoietic stem cell transplantation (haploHSCT). The aim was to relate a recent case of a rapid and progressive oral cGVHD after COVID-19. A 35-year-old man developed oral cGVHD only in the l...

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Detalles Bibliográficos
Autores principales: Vallejo, Pedro Henrique Cossu, Neto, Victor Tieghi, Nascimento, Ademilton Couto Do, De Lima, Emilze Mafra, Navarro, George Maurício, Varanda, Renata Freitas, Coracin, Fabio Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Mosby, Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381058/
http://dx.doi.org/10.1016/j.oooo.2022.01.247
Descripción
Sumario:Chronic graft-versus-host disease (cGVHD) is a common complication in patients undergoing haploidentical hematopoietic stem cell transplantation (haploHSCT). The aim was to relate a recent case of a rapid and progressive oral cGVHD after COVID-19. A 35-year-old man developed oral cGVHD only in the lips 190 days after haploHSCT for acute myelomonocytic leukemia. COVID-19 was diagnosed 263 days after haploHSCT and 5 days after donor lymphocyte infusion with improvement in his clinical condition after 1 week. Moreover, the patient reported rough changes in oral mucosa in 24 hours. Oral clinical exam showed extensive lichen planus–like changes in the whole oral mucosa in association with xerostomia, leading to a clinical oral cGVHD diagnosis. Both cGVHD and COVID-19 share high levels of inflammatory markers in their physiopathology, including interleukin 6 and TH-17 immune response. COVID-19 could contribute to oral lesions in association with donor lymphocytes.

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