EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity

EML4-ALK is an oncogenic fusion protein present in approximately 5% of non–small cell lung cancers (NSCLC). Alternative breakpoints in the gene encoding EML4 result in distinct variants that are linked to markedly different patient outcomes. Patients with EML4-ALK variant 3 (V3) respond poorly to AL...

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Detalles Bibliográficos
Autores principales: Lucken, Kellie, O'Regan, Laura, Choi, Jene, Sampson, Josephina, Pashley, Sarah L., Bayliss, Richard, Khan, Sam, Fry, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Cancer Genes and Networks
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381094/
https://www.ncbi.nlm.nih.gov/pubmed/35656694
http://dx.doi.org/10.1158/1541-7786.MCR-21-1010

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