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Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes

We hypothesize that the study of acute protein perturbation in signal transduction by targeted anticancer drugs can predict drug sensitivity of these agents used as single agents and rational combination therapy. We assayed dynamic changes in 52 phosphoproteins caused by an acute exposure (1 hour) t...

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Detalles Bibliográficos
Autores principales:	Coker, Elizabeth A., Stewart, Adam, Ozer, Bugra, Minchom, Anna, Pickard, Lisa, Ruddle, Ruth, Carreira, Suzanne, Popat, Sanjay, O'Brien, Mary, Raynaud, Florence, de Bono, Johann, Al-Lazikani, Bissan, Banerji, Udai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Targeting Drug Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381105/ https://www.ncbi.nlm.nih.gov/pubmed/35368084 http://dx.doi.org/10.1158/1535-7163.MCT-21-0442

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