Cargando…

Long Noncoding RNA LEMD1-AS1 Increases LEMD1 Expression and Activates PI3K-AKT Pathway to Promote Metastasis in Oral Squamous Cell Carcinoma

BACKGROUND: The survival rate of oral squamous cell carcinoma (OSCC) is only 50% due to a high incidence of metastasis. Long noncoding RNAs (lncRNAs) play a crucial role in OSCC genesis and progression, although their potential role in the metastasis of OSCC remains unclear. METHODS: The transcripto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Zaiye, Wang, Jie, Wu, Jianjun, Li, Ning, Jiang, Canhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381283/ https://www.ncbi.nlm.nih.gov/pubmed/35983249 http://dx.doi.org/10.1155/2022/3543948

Ejemplares similares

Downregulation of LEMD1-AS1 and Its Influences on the Diagnosis, Prognosis, and Immune Infiltrates of Epithelial Ovarian Cancer
por: Yang, Xiaoju, et al.
Publicado: (2022)

Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2
por: Abdelfatah, Nelly, et al.
Publicado: (2019)

Loss of function of the nuclear envelope protein LEMD2 causes DNA damage–dependent cardiomyopathy
por: Caravia, Xurde M., et al.
Publicado: (2022)

Genome-Wide Scan Reveals LEMD3 and WIF1 on SSC5 as the Candidates for Porcine Ear Size
por: Zhang, Longchao, et al.
Publicado: (2014)

LEMD1-AS1 Suppresses Ovarian Cancer Progression Through Regulating miR-183-5p/TP53 Axis
por: Guo, Ruowen, et al.
Publicado: (2020)

SATB2‐LEMD2 interaction links nuclear shape plasticity to regulation of cognition‐related genes
por: Feurle, Patrick, et al.
Publicado: (2020)

Osteopoikilosis and multiple exostoses caused by novel mutations in LEMD3 and EXT1 genes respectively - coincidence within one family
por: Baasanjav, Sevjidmaa, et al.
Publicado: (2010)

Mutation in LEMD3 (Man1) Associated with Osteopoikilosis and Late-Onset Generalized Morphea: A New Buschke-Ollendorf Syndrome Variant
por: Korman, Benjamin, et al.
Publicado: (2016)

Hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3
por: Ji, Dong, et al.
Publicado: (2020)

LEM domain containing 1 (LEMD1) transcriptionally activated by SRY-related high-mobility-group box 4 (SOX4) accelerates the progression of colon cancer by upregulating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway
por: Li, Ding, et al.
Publicado: (2022)

Using the C. elegans lem-2 Gene to Reconstruct the Human LEMD2 Mutation Associated with Hutterite-type Cataract/Cardiomyopathy
por: AlKhaleefa, Ayaa, et al.
Publicado: (2020)

A Three-Genes Signature Predicting Colorectal Cancer Relapse Reveals LEMD1 Promoting CRC Cells Migration by RhoA/ROCK1 Signaling Pathway
por: Zhang, Hui, et al.
Publicado: (2022)

Novel 4-bp Intronic Deletion (c.1560+3_1560+6del) in LEMD3 in a Korean Patient With Osteopoikilosis
por: Yoo, In Young, et al.
Publicado: (2017)

Erratum: Novel 4-bp Intronic Deletion (c.1560+3_1560+6del) in LEMD3 in a Korean Patient With Osteopoikilosis
Publicado: (2019)

The circEPSTI1/mir-942-5p/LTBP2 axis regulates the progression of OSCC in the background of OSF via EMT and the PI3K/Akt/mTOR pathway
por: Wang, Jie, et al.
Publicado: (2020)

Tc-99m MDP Bone SPECT/CT Findings of a Patient Detected with a New Mutation in LEMD3 Gene: A Case of Osteopoikilosis
por: Silov, Güler, et al.
Publicado: (2018)

Hutterite‐type cataract maps to chromosome 6p21.32‐p21.31, cosegregates with a homozygous mutation in LEMD2, and is associated with sudden cardiac death
por: Boone, Philip M., et al.
Publicado: (2015)

TCGA based integrated genomic analyses of ceRNA network and novel subtypes revealing potential biomarkers for the prognosis and target therapy of tongue squamous cell carcinoma
por: Li, Zaiye, et al.
Publicado: (2019)

ET-1 promotes the growth and metastasis of esophageal squamous cell carcinoma via activating PI3K/Akt pathway
por: Yin, Hui, et al.
Publicado: (2020)

TROP2 increases growth and metastasis of human oral squamous cell carcinoma through activation of the PI3K/Akt signaling pathway
por: Tang, Genxiong, et al.
Publicado: (2019)

HPRT1 Promotes Chemoresistance in Oral Squamous Cell Carcinoma via Activating MMP1/PI3K/Akt Signaling Pathway
por: Wu, Tong, et al.
Publicado: (2022)

CD147 promotes glucose metabolism, invasion and metastasis via PI3K/AKT pathway in oral squamous cell carcinomas
por: Huang, Yi, et al.
Publicado: (2019)

GABARAPL1 suppresses metastasis by counteracting PI3K/Akt pathway in prostate cancer
por: Su, Wei, et al.
Publicado: (2016)

HERG1 promotes esophageal squamous cell carcinoma growth and metastasis through TXNDC5 by activating the PI3K/AKT pathway
por: Wang, Hongqiang, et al.
Publicado: (2019)

Long noncoding RNA UCA1 facilitates cell proliferation and inhibits apoptosis in retinoblastoma by activating the PI3K/Akt pathway
por: Yuan, Zhongfang, et al.
Publicado: (2020)

Long noncoding RNA UCA1 promotes osteosarcoma metastasis through CREB1-mediated epithelial-mesenchymal transition and activating PI3K/AKT/mTOR pathway
por: Ma, Hangzhan, et al.
Publicado: (2019)

Long Noncoding RNAs in the Metastasis of Oral Squamous Cell Carcinoma
por: Xu, Yuming, et al.
Publicado: (2021)

High mobility group box 1 regulates tumor metastasis in cutaneous squamous cell carcinoma via the PI3K/AKT and MAPK signaling pathways
por: SUN, YING, et al.
Publicado: (2016)

Coculture of cancer cells with platelets increases their survival and metastasis by activating the TGFβ/Smad/PAI-1 and PI3K/AKT pathways
por: Tong, Haibo, et al.
Publicado: (2023)

LncRNA LOXL1-AS1 Promotes the Proliferation and Metastasis of Medulloblastoma by Activating the PI3K/AKT Pathway
por: Gao, Ran, et al.
Publicado: (2018)

Anlotinib Suppresses Oral Squamous Cell Carcinoma Growth and Metastasis by Targeting the RAS Protein to Inhibit the PI3K/Akt Signalling Pathway
por: Lu, Yunfei, et al.
Publicado: (2021)

Increasing effect of Tangzhiqing formula on IRS-1-dependent PI3K/AKT signaling in muscle
por: Gao, Jing, et al.
Publicado: (2014)

Long Noncoding RNA FGFR3-AS1 Promotes Hepatocellular Carcinoma Carcinogenesis via Modulating the PI3K/AKT Pathway
por: Zhuang, Juhua, et al.
Publicado: (2018)

Downregulation of FAP suppresses cell proliferation and metastasis through PTEN/PI3K/AKT and Ras-ERK signaling in oral squamous cell carcinoma
por: Wang, H, et al.
Publicado: (2014)

FERMT1 knockdown inhibits oral squamous cell carcinoma cell epithelial-mesenchymal transition by inactivating the PI3K/AKT signaling pathway
por: Wang, Xiao, et al.
Publicado: (2021)

Clinicopathological Significance of AKT1 and PLK1 Expression in Oral Squamous Cell Carcinoma
por: Sun, Er-Can, et al.
Publicado: (2022)

Tetraspanin 1 promotes epithelial-to-mesenchymal transition and metastasis of cholangiocarcinoma via PI3K/AKT signaling
por: Wang, Yan, et al.
Publicado: (2018)

AKR1B10 inhibits the proliferation and metastasis of hepatocellular carcinoma cells by regulating the PI3K/AKT pathway
por: Tian, Ke, et al.
Publicado: (2023)

Periostin promotes the proliferation and metastasis of osteosarcoma by increasing cell survival and activates the PI3K/Akt pathway
por: Xu, Chaojian, et al.
Publicado: (2022)

Long noncoding RNA SNHG1 promotes cell proliferation through PI3K/AKT signaling pathway in pancreatic ductal adenocarcinoma
por: Zhang, Yalu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_70m8a7fapup62k4knlus3drv6i