Autoimmune Pancreatitis with Gastric Cancer: Some IgG4-related Diseases May Be Paraneoplastic Syndrome

A 70-year-old man was referred to our department for the treatment of early gastric cancer. Contrast-enhanced computed tomography (CT) incidentally showed diffuse enlargement of the pancreas with a capsule-like rim, and blood tests showed elevated serum IgG4 levels, leading to a diagnosis of autoimm...

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Detalles Bibliográficos
Autores principales: Miyagawa, Koichiro, Kumamoto, Keiichiro, Shinohara, Nobuhiko, Watanabe, Tatsuyuki, Kumei, Shinsuke, Yoneda, Akitoshi, Nebuya, Satoru, Koya, Yudai, Oe, Shinji, Kume, Keiichiro, Yoshikawa, Ichiro, Harada, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381340/
https://www.ncbi.nlm.nih.gov/pubmed/35850987
http://dx.doi.org/10.2169/internalmedicine.8590-21
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author Miyagawa, Koichiro
Kumamoto, Keiichiro
Shinohara, Nobuhiko
Watanabe, Tatsuyuki
Kumei, Shinsuke
Yoneda, Akitoshi
Nebuya, Satoru
Koya, Yudai
Oe, Shinji
Kume, Keiichiro
Yoshikawa, Ichiro
Harada, Masaru
author_facet Miyagawa, Koichiro
Kumamoto, Keiichiro
Shinohara, Nobuhiko
Watanabe, Tatsuyuki
Kumei, Shinsuke
Yoneda, Akitoshi
Nebuya, Satoru
Koya, Yudai
Oe, Shinji
Kume, Keiichiro
Yoshikawa, Ichiro
Harada, Masaru
author_sort Miyagawa, Koichiro
collection PubMed
description A 70-year-old man was referred to our department for the treatment of early gastric cancer. Contrast-enhanced computed tomography (CT) incidentally showed diffuse enlargement of the pancreas with a capsule-like rim, and blood tests showed elevated serum IgG4 levels, leading to a diagnosis of autoimmune pancreatitis (AIP). Endoscopic treatment for gastric cancer was performed, and pathological findings showed adenocarcinoma with abundant IgG4-positive plasma cell infiltration. Thereafter, the serum IgG4 levels normalized, and the findings of AIP disappeared on CT without steroid treatment. These findings suggest that the gastric cancer activated an IgG4-related immune response, resulting in the development of AIP.
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spelling pubmed-93813402022-08-31 Autoimmune Pancreatitis with Gastric Cancer: Some IgG4-related Diseases May Be Paraneoplastic Syndrome Miyagawa, Koichiro Kumamoto, Keiichiro Shinohara, Nobuhiko Watanabe, Tatsuyuki Kumei, Shinsuke Yoneda, Akitoshi Nebuya, Satoru Koya, Yudai Oe, Shinji Kume, Keiichiro Yoshikawa, Ichiro Harada, Masaru Intern Med Case Report A 70-year-old man was referred to our department for the treatment of early gastric cancer. Contrast-enhanced computed tomography (CT) incidentally showed diffuse enlargement of the pancreas with a capsule-like rim, and blood tests showed elevated serum IgG4 levels, leading to a diagnosis of autoimmune pancreatitis (AIP). Endoscopic treatment for gastric cancer was performed, and pathological findings showed adenocarcinoma with abundant IgG4-positive plasma cell infiltration. Thereafter, the serum IgG4 levels normalized, and the findings of AIP disappeared on CT without steroid treatment. These findings suggest that the gastric cancer activated an IgG4-related immune response, resulting in the development of AIP. The Japanese Society of Internal Medicine 2022-07-15 2022-07-15 /pmc/articles/PMC9381340/ /pubmed/35850987 http://dx.doi.org/10.2169/internalmedicine.8590-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Miyagawa, Koichiro
Kumamoto, Keiichiro
Shinohara, Nobuhiko
Watanabe, Tatsuyuki
Kumei, Shinsuke
Yoneda, Akitoshi
Nebuya, Satoru
Koya, Yudai
Oe, Shinji
Kume, Keiichiro
Yoshikawa, Ichiro
Harada, Masaru
Autoimmune Pancreatitis with Gastric Cancer: Some IgG4-related Diseases May Be Paraneoplastic Syndrome
title Autoimmune Pancreatitis with Gastric Cancer: Some IgG4-related Diseases May Be Paraneoplastic Syndrome
title_full Autoimmune Pancreatitis with Gastric Cancer: Some IgG4-related Diseases May Be Paraneoplastic Syndrome
title_fullStr Autoimmune Pancreatitis with Gastric Cancer: Some IgG4-related Diseases May Be Paraneoplastic Syndrome
title_full_unstemmed Autoimmune Pancreatitis with Gastric Cancer: Some IgG4-related Diseases May Be Paraneoplastic Syndrome
title_short Autoimmune Pancreatitis with Gastric Cancer: Some IgG4-related Diseases May Be Paraneoplastic Syndrome
title_sort autoimmune pancreatitis with gastric cancer: some igg4-related diseases may be paraneoplastic syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381340/
https://www.ncbi.nlm.nih.gov/pubmed/35850987
http://dx.doi.org/10.2169/internalmedicine.8590-21
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