Wild-type Transthyretin Amyloidosis with Diffuse Alveolar-septal Amyloidosis Diagnosed by a Transbronchial Lung Biopsy

A 69-year-old man visited our pulmonary medicine department for dyspnea. Chest computed tomography (CT) revealed ground-glass opacity bilaterally in the lungs. Upon performing a transbronchial lung biopsy (TBLB), organizing pneumonia was diagnosed. His electrocardiogram revealed low voltage, and the...

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Autores principales: Ishida, Masaki, Enomoto, Masamitsu, Hata, Tae, Tanaka, Tomoki, Sakaguchi, Chikara, Tamiya, Nobuyo, Tsuchiya, Michiko, Nagasaka, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381353/
https://www.ncbi.nlm.nih.gov/pubmed/35850989
http://dx.doi.org/10.2169/internalmedicine.8521-21
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author Ishida, Masaki
Enomoto, Masamitsu
Hata, Tae
Tanaka, Tomoki
Sakaguchi, Chikara
Tamiya, Nobuyo
Tsuchiya, Michiko
Nagasaka, Yukio
author_facet Ishida, Masaki
Enomoto, Masamitsu
Hata, Tae
Tanaka, Tomoki
Sakaguchi, Chikara
Tamiya, Nobuyo
Tsuchiya, Michiko
Nagasaka, Yukio
author_sort Ishida, Masaki
collection PubMed
description A 69-year-old man visited our pulmonary medicine department for dyspnea. Chest computed tomography (CT) revealed ground-glass opacity bilaterally in the lungs. Upon performing a transbronchial lung biopsy (TBLB), organizing pneumonia was diagnosed. His electrocardiogram revealed low voltage, and the cardiac ultrasound revealed hypertrophy of the interventricular septum. The patient had bilateral carpal tunnel syndrome, and amyloidosis was suspected. Congo red stain was added to the lung biopsy specimen. Amyloid deposition of transthyretin (ATTR) was positive, mutations with amino acid changes were not observed in the TTR gene. Wild-type ATTR Amyloidosis (ATTRwt amyloidosis) was diagnosed using a TBLB. Chest CT after treatment with steroids revealed diffuse alveolar-septal amyloidosis.
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spelling pubmed-93813532022-08-31 Wild-type Transthyretin Amyloidosis with Diffuse Alveolar-septal Amyloidosis Diagnosed by a Transbronchial Lung Biopsy Ishida, Masaki Enomoto, Masamitsu Hata, Tae Tanaka, Tomoki Sakaguchi, Chikara Tamiya, Nobuyo Tsuchiya, Michiko Nagasaka, Yukio Intern Med Case Report A 69-year-old man visited our pulmonary medicine department for dyspnea. Chest computed tomography (CT) revealed ground-glass opacity bilaterally in the lungs. Upon performing a transbronchial lung biopsy (TBLB), organizing pneumonia was diagnosed. His electrocardiogram revealed low voltage, and the cardiac ultrasound revealed hypertrophy of the interventricular septum. The patient had bilateral carpal tunnel syndrome, and amyloidosis was suspected. Congo red stain was added to the lung biopsy specimen. Amyloid deposition of transthyretin (ATTR) was positive, mutations with amino acid changes were not observed in the TTR gene. Wild-type ATTR Amyloidosis (ATTRwt amyloidosis) was diagnosed using a TBLB. Chest CT after treatment with steroids revealed diffuse alveolar-septal amyloidosis. The Japanese Society of Internal Medicine 2022-07-15 2022-07-15 /pmc/articles/PMC9381353/ /pubmed/35850989 http://dx.doi.org/10.2169/internalmedicine.8521-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ishida, Masaki
Enomoto, Masamitsu
Hata, Tae
Tanaka, Tomoki
Sakaguchi, Chikara
Tamiya, Nobuyo
Tsuchiya, Michiko
Nagasaka, Yukio
Wild-type Transthyretin Amyloidosis with Diffuse Alveolar-septal Amyloidosis Diagnosed by a Transbronchial Lung Biopsy
title Wild-type Transthyretin Amyloidosis with Diffuse Alveolar-septal Amyloidosis Diagnosed by a Transbronchial Lung Biopsy
title_full Wild-type Transthyretin Amyloidosis with Diffuse Alveolar-septal Amyloidosis Diagnosed by a Transbronchial Lung Biopsy
title_fullStr Wild-type Transthyretin Amyloidosis with Diffuse Alveolar-septal Amyloidosis Diagnosed by a Transbronchial Lung Biopsy
title_full_unstemmed Wild-type Transthyretin Amyloidosis with Diffuse Alveolar-septal Amyloidosis Diagnosed by a Transbronchial Lung Biopsy
title_short Wild-type Transthyretin Amyloidosis with Diffuse Alveolar-septal Amyloidosis Diagnosed by a Transbronchial Lung Biopsy
title_sort wild-type transthyretin amyloidosis with diffuse alveolar-septal amyloidosis diagnosed by a transbronchial lung biopsy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381353/
https://www.ncbi.nlm.nih.gov/pubmed/35850989
http://dx.doi.org/10.2169/internalmedicine.8521-21
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