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Developmental Abnormalities of Teeth in Children With Nephrotic Syndrome

INTRODUCTION: Treatment with glucocorticoids in children with nephrotic syndrome can be the cause of developmental disorders of the masticatory organ and bone or teeth abnormalities. The aim was to assess the frequency and type of dental abnormalities and the correlation of their occurrence with a d...

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Autores principales: Piekoszewska-Ziętek, Paula, Olczak-Kowalczyk, Dorota, Pańczyk-Tomaszewska, Małgorzata, Gozdowski, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381380/
https://www.ncbi.nlm.nih.gov/pubmed/35277264
http://dx.doi.org/10.1016/j.identj.2021.11.014
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author Piekoszewska-Ziętek, Paula
Olczak-Kowalczyk, Dorota
Pańczyk-Tomaszewska, Małgorzata
Gozdowski, Dariusz
author_facet Piekoszewska-Ziętek, Paula
Olczak-Kowalczyk, Dorota
Pańczyk-Tomaszewska, Małgorzata
Gozdowski, Dariusz
author_sort Piekoszewska-Ziętek, Paula
collection PubMed
description INTRODUCTION: Treatment with glucocorticoids in children with nephrotic syndrome can be the cause of developmental disorders of the masticatory organ and bone or teeth abnormalities. The aim was to assess the frequency and type of dental abnormalities and the correlation of their occurrence with a dosage of glucocorticoids and treatment time in children with idiopathic nephrotic syndrome. METHODS: The study group consisted of 31 patients aged 5 to 17 diagnosed with idiopathic steroid-sensitive nephrotic syndrome and 33 overall healthy children. The studies included clinical evaluation of dentition, radiologic diagnostics, and statistical analysis. RESULTS: In the study group, 77.4% of patients were diagnosed with abnormalities in dental development. Tooth number disorders, presence of persistent deciduous teeth and impacted teeth, abnormal crown or root shape, developmental defects of enamel, pulp stones, and bone structure disorders were identified. Statistical analysis showed significant differences in the average treatment time of glucocorticoids in patients without and with tooth developmental abnormalities. CONCLUSIONS: Long-term use of glucocorticoids in children with nephrotic syndrome promotes the occurrence of developmental abnormalities of the teeth, calcification of the pulp, and disorders of bone tissue metabolism. For this reason, patients with steroid-sensitive nephrotic syndrome should be under the constant care of a dentist.
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spelling pubmed-93813802022-08-18 Developmental Abnormalities of Teeth in Children With Nephrotic Syndrome Piekoszewska-Ziętek, Paula Olczak-Kowalczyk, Dorota Pańczyk-Tomaszewska, Małgorzata Gozdowski, Dariusz Int Dent J Scientific Research Report INTRODUCTION: Treatment with glucocorticoids in children with nephrotic syndrome can be the cause of developmental disorders of the masticatory organ and bone or teeth abnormalities. The aim was to assess the frequency and type of dental abnormalities and the correlation of their occurrence with a dosage of glucocorticoids and treatment time in children with idiopathic nephrotic syndrome. METHODS: The study group consisted of 31 patients aged 5 to 17 diagnosed with idiopathic steroid-sensitive nephrotic syndrome and 33 overall healthy children. The studies included clinical evaluation of dentition, radiologic diagnostics, and statistical analysis. RESULTS: In the study group, 77.4% of patients were diagnosed with abnormalities in dental development. Tooth number disorders, presence of persistent deciduous teeth and impacted teeth, abnormal crown or root shape, developmental defects of enamel, pulp stones, and bone structure disorders were identified. Statistical analysis showed significant differences in the average treatment time of glucocorticoids in patients without and with tooth developmental abnormalities. CONCLUSIONS: Long-term use of glucocorticoids in children with nephrotic syndrome promotes the occurrence of developmental abnormalities of the teeth, calcification of the pulp, and disorders of bone tissue metabolism. For this reason, patients with steroid-sensitive nephrotic syndrome should be under the constant care of a dentist. Elsevier 2022-03-08 /pmc/articles/PMC9381380/ /pubmed/35277264 http://dx.doi.org/10.1016/j.identj.2021.11.014 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Scientific Research Report
Piekoszewska-Ziętek, Paula
Olczak-Kowalczyk, Dorota
Pańczyk-Tomaszewska, Małgorzata
Gozdowski, Dariusz
Developmental Abnormalities of Teeth in Children With Nephrotic Syndrome
title Developmental Abnormalities of Teeth in Children With Nephrotic Syndrome
title_full Developmental Abnormalities of Teeth in Children With Nephrotic Syndrome
title_fullStr Developmental Abnormalities of Teeth in Children With Nephrotic Syndrome
title_full_unstemmed Developmental Abnormalities of Teeth in Children With Nephrotic Syndrome
title_short Developmental Abnormalities of Teeth in Children With Nephrotic Syndrome
title_sort developmental abnormalities of teeth in children with nephrotic syndrome
topic Scientific Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381380/
https://www.ncbi.nlm.nih.gov/pubmed/35277264
http://dx.doi.org/10.1016/j.identj.2021.11.014
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