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Manipulation of the inflammatory reflex as a therapeutic strategy

The cholinergic anti-inflammatory pathway is the efferent arm of the inflammatory reflex, a neural circuit through which the CNS can modulate peripheral immune responses. Signals communicated via the vagus and splenic nerves use acetylcholine, produced by Choline acetyltransferase (ChAT)+ T cells, t...

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Detalles Bibliográficos
Autores principales: Kelly, Mark J., Breathnach, Caitríona, Tracey, Kevin J., Donnelly, Seamas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381415/
https://www.ncbi.nlm.nih.gov/pubmed/35858588
http://dx.doi.org/10.1016/j.xcrm.2022.100696
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author Kelly, Mark J.
Breathnach, Caitríona
Tracey, Kevin J.
Donnelly, Seamas C.
author_facet Kelly, Mark J.
Breathnach, Caitríona
Tracey, Kevin J.
Donnelly, Seamas C.
author_sort Kelly, Mark J.
collection PubMed
description The cholinergic anti-inflammatory pathway is the efferent arm of the inflammatory reflex, a neural circuit through which the CNS can modulate peripheral immune responses. Signals communicated via the vagus and splenic nerves use acetylcholine, produced by Choline acetyltransferase (ChAT)+ T cells, to downregulate the inflammatory actions of macrophages expressing α7 nicotinic receptors. Pre-clinical studies using transgenic animals, cholinergic agonists, vagotomy, and vagus nerve stimulation have demonstrated this pathway’s role and therapeutic potential in numerous inflammatory diseases. In this review, we summarize what is understood about the inflammatory reflex. We also demonstrate how pre-clinical findings are being translated into promising clinical trials, and we draw particular attention to innovative bioelectronic methods of harnessing the cholinergic anti-inflammatory pathway for clinical use.
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spelling pubmed-93814152022-08-18 Manipulation of the inflammatory reflex as a therapeutic strategy Kelly, Mark J. Breathnach, Caitríona Tracey, Kevin J. Donnelly, Seamas C. Cell Rep Med Review The cholinergic anti-inflammatory pathway is the efferent arm of the inflammatory reflex, a neural circuit through which the CNS can modulate peripheral immune responses. Signals communicated via the vagus and splenic nerves use acetylcholine, produced by Choline acetyltransferase (ChAT)+ T cells, to downregulate the inflammatory actions of macrophages expressing α7 nicotinic receptors. Pre-clinical studies using transgenic animals, cholinergic agonists, vagotomy, and vagus nerve stimulation have demonstrated this pathway’s role and therapeutic potential in numerous inflammatory diseases. In this review, we summarize what is understood about the inflammatory reflex. We also demonstrate how pre-clinical findings are being translated into promising clinical trials, and we draw particular attention to innovative bioelectronic methods of harnessing the cholinergic anti-inflammatory pathway for clinical use. Elsevier 2022-07-19 /pmc/articles/PMC9381415/ /pubmed/35858588 http://dx.doi.org/10.1016/j.xcrm.2022.100696 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kelly, Mark J.
Breathnach, Caitríona
Tracey, Kevin J.
Donnelly, Seamas C.
Manipulation of the inflammatory reflex as a therapeutic strategy
title Manipulation of the inflammatory reflex as a therapeutic strategy
title_full Manipulation of the inflammatory reflex as a therapeutic strategy
title_fullStr Manipulation of the inflammatory reflex as a therapeutic strategy
title_full_unstemmed Manipulation of the inflammatory reflex as a therapeutic strategy
title_short Manipulation of the inflammatory reflex as a therapeutic strategy
title_sort manipulation of the inflammatory reflex as a therapeutic strategy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381415/
https://www.ncbi.nlm.nih.gov/pubmed/35858588
http://dx.doi.org/10.1016/j.xcrm.2022.100696
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