Cerebral microvascular complications associated with SARS-CoV-2 infection: How did it occur and how should it be treated?

Cerebral microvascular disease has been reported as a central feature of the neurological disorders in patients with SARS-CoV-2 infection that may be associated with an increased risk of ischemic stroke. The main pathomechanism in the development of cerebrovascular injury due to SARS-CoV-2 infection...

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Autores principales: Omidian, Neda, Mohammadi, Pantea, Sadeghalvad, Mona, Mohammadi-Motlagh, Hamid-Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Masson SAS. 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381434/
https://www.ncbi.nlm.nih.gov/pubmed/35994816
http://dx.doi.org/10.1016/j.biopha.2022.113534
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author Omidian, Neda
Mohammadi, Pantea
Sadeghalvad, Mona
Mohammadi-Motlagh, Hamid-Reza
author_facet Omidian, Neda
Mohammadi, Pantea
Sadeghalvad, Mona
Mohammadi-Motlagh, Hamid-Reza
author_sort Omidian, Neda
collection PubMed
description Cerebral microvascular disease has been reported as a central feature of the neurological disorders in patients with SARS-CoV-2 infection that may be associated with an increased risk of ischemic stroke. The main pathomechanism in the development of cerebrovascular injury due to SARS-CoV-2 infection can be a consequence of endothelial cell dysfunction as a structural part of the blood-brain barrier (BBB), which may be accompanied by increased inflammatory response and thrombocytopenia along with blood coagulation disorders. In this review, we described the properties of the BBB, the neurotropism behavior of SARS-CoV-2, and the possible mechanisms of damage to the CNS microvascular upon SARS-CoV-2 infection.
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spelling pubmed-93814342022-08-17 Cerebral microvascular complications associated with SARS-CoV-2 infection: How did it occur and how should it be treated? Omidian, Neda Mohammadi, Pantea Sadeghalvad, Mona Mohammadi-Motlagh, Hamid-Reza Biomed Pharmacother Review Cerebral microvascular disease has been reported as a central feature of the neurological disorders in patients with SARS-CoV-2 infection that may be associated with an increased risk of ischemic stroke. The main pathomechanism in the development of cerebrovascular injury due to SARS-CoV-2 infection can be a consequence of endothelial cell dysfunction as a structural part of the blood-brain barrier (BBB), which may be accompanied by increased inflammatory response and thrombocytopenia along with blood coagulation disorders. In this review, we described the properties of the BBB, the neurotropism behavior of SARS-CoV-2, and the possible mechanisms of damage to the CNS microvascular upon SARS-CoV-2 infection. The Authors. Published by Elsevier Masson SAS. 2022-10 2022-08-17 /pmc/articles/PMC9381434/ /pubmed/35994816 http://dx.doi.org/10.1016/j.biopha.2022.113534 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Omidian, Neda
Mohammadi, Pantea
Sadeghalvad, Mona
Mohammadi-Motlagh, Hamid-Reza
Cerebral microvascular complications associated with SARS-CoV-2 infection: How did it occur and how should it be treated?
title Cerebral microvascular complications associated with SARS-CoV-2 infection: How did it occur and how should it be treated?
title_full Cerebral microvascular complications associated with SARS-CoV-2 infection: How did it occur and how should it be treated?
title_fullStr Cerebral microvascular complications associated with SARS-CoV-2 infection: How did it occur and how should it be treated?
title_full_unstemmed Cerebral microvascular complications associated with SARS-CoV-2 infection: How did it occur and how should it be treated?
title_short Cerebral microvascular complications associated with SARS-CoV-2 infection: How did it occur and how should it be treated?
title_sort cerebral microvascular complications associated with sars-cov-2 infection: how did it occur and how should it be treated?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381434/
https://www.ncbi.nlm.nih.gov/pubmed/35994816
http://dx.doi.org/10.1016/j.biopha.2022.113534
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