Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by aberrant alternative splicing (AS). Nuclear loss and cytoplasmic accumulation of the splicing factor TDP-43 in motor neurons (MN) are hallmarks of ALS at late stages of the disease. However, it is unknown if altered AS is presen...

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Detalles Bibliográficos
Autores principales: Krach, Florian, Wheeler, Emily C., Regensburger, Martin, Boerstler, Tom, Wend, Holger, Vu, Anthony Q., Wang, Ruth, Reischl, Stephanie, Boldt, Karsten, Batra, Ranjan, Aigner, Stefan, Ravits, John, Winkler, Juergen, Yeo, Gene W., Winner, Beate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381448/
https://www.ncbi.nlm.nih.gov/pubmed/35778567
http://dx.doi.org/10.1007/s00401-022-02450-3

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