Single-cell DNA sequencing identifies risk-associated clonal complexity and evolutionary trajectories in childhood medulloblastoma development

We reconstructed the natural history and temporal evolution of the most common childhood brain malignancy, medulloblastoma, by single-cell whole-genome sequencing (sc-WGS) of tumours representing its major molecular sub-classes and clinical risk groups. Favourable-risk disease sub-types assessed (MB...

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Detalles Bibliográficos
Autores principales: Danilenko, Marina, Zaka, Masood, Keeling, Claire, Crosier, Stephen, Lyman, Stephanie, Finetti, Martina, Williamson, Daniel, Hussain, Rafiqul, Coxhead, Jonathan, Zhou, Peixun, Hill, Rebecca M., Hicks, Debbie, Rand, Vikki, Joshi, Abhijit, Schwalbe, Edward C., Bailey, Simon, Clifford, Steven C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381458/
https://www.ncbi.nlm.nih.gov/pubmed/35831448
http://dx.doi.org/10.1007/s00401-022-02464-x

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