Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes

Sensing of cytosolic DNA of microbial or cellular/mitochondrial origin by cGAS initiates innate immune responses via the adaptor protein STING. It remains unresolved how the activity of STING is balanced between a productive innate immune response and induction of autoimmunity. Here we show that int...

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Detalles Bibliográficos
Autores principales: Luo, Wei-Wei, Tong, Zhen, Cao, Pan, Wang, Fu-Bing, Liu, Ying, Zheng, Zhou-Qin, Wang, Su-Yun, Li, Shu, Wang, Yan-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381507/
https://www.ncbi.nlm.nih.gov/pubmed/35973990
http://dx.doi.org/10.1038/s41467-022-32401-1

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