Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma

How the glioma immune microenvironment fosters tumorigenesis remains incompletely defined. Here, we use single-cell RNA-sequencing and multiplexed tissue-imaging to characterize the composition, spatial organization, and clinical significance of extracellular purinergic signaling in glioma. We show...

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Detalles Bibliográficos
Autores principales: Coy, Shannon, Wang, Shu, Stopka, Sylwia A., Lin, Jia-Ren, Yapp, Clarence, Ritch, Cecily C., Salhi, Lisa, Baker, Gregory J., Rashid, Rumana, Baquer, Gerard, Regan, Michael, Khadka, Prasidda, Cole, Kristina A., Hwang, Jaeho, Wen, Patrick Y., Bandopadhayay, Pratiti, Santi, Mariarita, De Raedt, Thomas, Ligon, Keith L., Agar, Nathalie Y. R., Sorger, Peter K., Touat, Mehdi, Santagata, Sandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381513/
https://www.ncbi.nlm.nih.gov/pubmed/35973991
http://dx.doi.org/10.1038/s41467-022-32430-w

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