Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia

Classifications of acute myeloid leukemia (AML) patients rely on morphologic, cytogenetic, and molecular features. Here we have established a novel flow cytometry-based immunophenotypic stratification showing that AML blasts are blocked at specific stages of differentiation where features of normal...

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Detalles Bibliográficos
Autores principales: Vergez, François, Largeaud, Laetitia, Bertoli, Sarah, Nicolau, Marie-Laure, Rieu, Jean-Baptiste, Vergnolle, Inès, Saland, Estelle, Sarry, Audrey, Tavitian, Suzanne, Huguet, Françoise, Picard, Muriel, Vial, Jean-Philippe, Lechevalier, Nicolas, Bidet, Audrey, Dumas, Pierre-Yves, Pigneux, Arnaud, Luquet, Isabelle, Mansat-De Mas, Véronique, Delabesse, Eric, Carroll, Martin, Danet-Desnoyers, Gwenn, Sarry, Jean-Emmanuel, Récher, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381519/
https://www.ncbi.nlm.nih.gov/pubmed/35973983
http://dx.doi.org/10.1038/s41408-022-00712-7

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