Cargando…

The addition of FAIMS increases targeted proteomics sensitivity from FFPE tumor biopsies

Mass spectrometry-based targeted proteomics allows objective protein quantitation of clinical biomarkers from a single section of formalin-fixed, paraffin-embedded (FFPE) tumor tissue biopsies. We combined high-field asymmetric waveform ion mobility spectrometry (FAIMS) and parallel reaction monitor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sweet, Steve, Chain, David, Yu, Wen, Martin, Philip, Rebelatto, Marlon, Chambers, Andrew, Cecchi, Fabiola, Kim, Yeoun Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381555/ https://www.ncbi.nlm.nih.gov/pubmed/35974054 http://dx.doi.org/10.1038/s41598-022-16358-1

Ejemplares similares

Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue
por: Chambers, Andrew G., et al.
Publicado: (2023)

Benefits of FAIMS to Improve the Proteome Coverage of Deteriorated and/or Cross-Linked TMT 10-Plex FFPE Tissue and Plasma-Derived Exosomes Samples
por: Montero-Calle, Ana, et al.
Publicado: (2023)

La faim
por: Hamsun, Knut, 1859-1952
Publicado: (1945)

Probing the Complementarity of FAIMS and Strong Cation Exchange Chromatography in Shotgun Proteomics
por: Creese, Andrew J., et al.
Publicado: (2013)

Evaluation of Fast and Sensitive Proteome Profiling of FF and FFPE Kidney Patient Tissues
por: Dapic, Irena, et al.
Publicado: (2022)

A fully automated FAIMS-DIA mass spectrometry-based proteomic pipeline
por: Reilly, Luke, et al.
Publicado: (2023)

SimFFPE and FilterFFPE: improving structural variant calling in FFPE samples
por: Wei, Lanying, et al.
Publicado: (2021)

Comparative proteomic analysis of children FSGS FFPE tissues
por: Ni, Jiajia, et al.
Publicado: (2022)

A High-Throughput Workflow for FFPE Tissue Proteomics
por: Pujari, Ganesh P., et al.
Publicado: (2023)

FAIM: An Antagonist of Fas-Killing and Beyond
por: Huo, Jianxin, et al.
Publicado: (2019)

Acetone Sensor Based on FAIMS-MEMS
por: Zhang, Junna, et al.
Publicado: (2021)

Destruction massive - Géopolitique de la faim
por: Ziegler, Jean
Publicado: (2012)

To What Extent is FAIMS Beneficial in the Analysis of Proteins?
por: Cooper, Helen J.
Publicado: (2016)

FAIMS Enhances the Detection of PTM Crosstalk Sites
por: Adoni, Kish R., et al.
Publicado: (2022)

Toward deciphering proteomes of formalin-fixed paraffin-embedded (FFPE) tissues
por: Magdeldin, Sameh, et al.
Publicado: (2012)

A Pilot Study of Rare Renal Amyloidosis Based on FFPE Proteomics
por: Meng, Shuang, et al.
Publicado: (2021)

FAIM regulates autophagy through glutaminolysis in lung adenocarcinoma
por: Han, Tianyu, et al.
Publicado: (2021)

False-Positive Glycopeptide Identification via In-FAIMS Fragmentation
por: Rangel-Angarita, Valentina, et al.
Publicado: (2023)

A Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients
por: Bekker-Jensen, Dorte B., et al.
Publicado: (2020)

High‐throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification
por: Zhu, Yi, et al.
Publicado: (2019)

Integrative proteomic characterization of trace FFPE samples in early-stage gastrointestinal cancer
por: Li, Lingling, et al.
Publicado: (2022)

La faim et les moyens, par Frédéric Lemaître
Publicado: (2009)

MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness
por: Planells-Ferrer, L, et al.
Publicado: (2014)

Separation of cis and trans Isomers of Polyproline by FAIMS Mass Spectrometry
por: Creese, Andrew J., et al.
Publicado: (2016)

FAIM2 is correlated with metastasis of medulloblastoma through bioinformatics analysis
por: Zhou, Xiaojun, et al.
Publicado: (2023)

Multi-Channel MEMS-FAIMS Gas Sensor for VOCs Detection
por: Zhao, Zhujie, et al.
Publicado: (2023)

A Non-Hazardous Deparaffinization Protocol Enables Quantitative Proteomics of Core Needle Biopsy-Sized Formalin-Fixed and Paraffin-Embedded (FFPE) Tissue Specimens
por: Mitsa, Georgia, et al.
Publicado: (2022)

Multiplexed characterization of cancer immune response in FFPE biopsies - initial performance of a new approach
por: Wang, Chichung, et al.
Publicado: (2013)

Proteomic Analysis of Prostate Cancer FFPE Samples Reveals Markers of Disease Progression and Aggressiveness
por: Lygirou, Vasiliki, et al.
Publicado: (2022)

Common rs7138803 variant of FAIM2 and obesity in Han Chinese
por: Li, Cong, et al.
Publicado: (2013)

On-Line Mixture Quantification to Track Temporal Change of Composition Using FAIMS
por: Yokoshiki, Yasufumi, et al.
Publicado: (2019)

Quantitative Profiling of the Human Substantia Nigra Proteome from Laser-capture Microdissected FFPE Tissue
por: Griesser, Eva, et al.
Publicado: (2020)

Straightforward and sensitive RT-qPCR based gene expression analysis of FFPE samples
por: Zeka, Fjoralba, et al.
Publicado: (2016)

Identification and characterization of new isoforms of human fas apoptotic inhibitory molecule (FAIM)
por: Coccia, Elena, et al.
Publicado: (2017)

PACAP ameliorates hepatic metabolism and inflammation through up‐regulating FAIM in obesity
por: Xiao, Xing, et al.
Publicado: (2019)

A needle-to-post air discharge ion source in tandem with FAIMS system
por: Li, Hua, et al.
Publicado: (2019)

Comprehensive LESA Mass Spectrometry Imaging of Intact Proteins by Integration of Cylindrical FAIMS
por: Griffiths, Rian L., et al.
Publicado: (2020)

Identification of Specific Substances in the FAIMS Spectra of Complex Mixtures Using Deep Learning
por: Li, Hua, et al.
Publicado: (2021)

FAIM2 is a potential pan-cancer biomarker for prognosis and immune infiltration
por: Cai, Jiayang, et al.
Publicado: (2022)

A critical spotlight on the paradigms of FFPE-DNA sequencing
por: Steiert, Tim A, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_1t2gnvi1vhfjbsn8el2fqij8vp