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Intereye structure–function relationship using photopic negative response in patients with glaucoma or glaucoma suspect
We evaluated the intereye structure–function relationship in glaucoma patients using photopic negative response in electroretinogram analysis. Patients with confirmed glaucoma (36 eyes, 36 patients) or suspected glaucoma (19 eyes, 19 patients) were included in this study. Electroretinogram (RETI-sca...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381565/ https://www.ncbi.nlm.nih.gov/pubmed/35974025 http://dx.doi.org/10.1038/s41598-022-17868-8 |
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author | Lee, Jihye Kim, Seong Ah Lee, Jiyun Park, Chan Kee Jung, Kyoung In |
author_facet | Lee, Jihye Kim, Seong Ah Lee, Jiyun Park, Chan Kee Jung, Kyoung In |
author_sort | Lee, Jihye |
collection | PubMed |
description | We evaluated the intereye structure–function relationship in glaucoma patients using photopic negative response in electroretinogram analysis. Patients with confirmed glaucoma (36 eyes, 36 patients) or suspected glaucoma (19 eyes, 19 patients) were included in this study. Electroretinogram (RETI-scan) was performed with red stimulus on blue background. Intereye comparison for 55 patients was performed between better eyes and worse eyes, which were divided based on average retinal nerve fiber layer (RNFL) thickness measured using spectral-domain optical coherence tomography. In the intereye analysis, PhNR amplitude was lower in worse eyes than in better eyes (P < 0.001). The intereye difference in PhNR amplitude was significantly correlated with intereye difference in average RNFL, as well as average or minimum ganglion cell-inner plexiform layer (GCIPL) thickness (P = 0.006, 0.044, 0.001). In patients with mean deviation ≥ − 6 dB of worse eyes, the intereye difference in PhNR amplitude was significantly associated with intereye difference in average RNFL thickness or minimum GCIPL thickness (P = 0.037, 0.007), but significant correlation was not found between mean sensitivity of visual field tests and structural parameters. In conclusion, PhNR performed well with regard to intereye structure–function association in glaucoma patients, especially at the early stage. |
format | Online Article Text |
id | pubmed-9381565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-93815652022-08-18 Intereye structure–function relationship using photopic negative response in patients with glaucoma or glaucoma suspect Lee, Jihye Kim, Seong Ah Lee, Jiyun Park, Chan Kee Jung, Kyoung In Sci Rep Article We evaluated the intereye structure–function relationship in glaucoma patients using photopic negative response in electroretinogram analysis. Patients with confirmed glaucoma (36 eyes, 36 patients) or suspected glaucoma (19 eyes, 19 patients) were included in this study. Electroretinogram (RETI-scan) was performed with red stimulus on blue background. Intereye comparison for 55 patients was performed between better eyes and worse eyes, which were divided based on average retinal nerve fiber layer (RNFL) thickness measured using spectral-domain optical coherence tomography. In the intereye analysis, PhNR amplitude was lower in worse eyes than in better eyes (P < 0.001). The intereye difference in PhNR amplitude was significantly correlated with intereye difference in average RNFL, as well as average or minimum ganglion cell-inner plexiform layer (GCIPL) thickness (P = 0.006, 0.044, 0.001). In patients with mean deviation ≥ − 6 dB of worse eyes, the intereye difference in PhNR amplitude was significantly associated with intereye difference in average RNFL thickness or minimum GCIPL thickness (P = 0.037, 0.007), but significant correlation was not found between mean sensitivity of visual field tests and structural parameters. In conclusion, PhNR performed well with regard to intereye structure–function association in glaucoma patients, especially at the early stage. Nature Publishing Group UK 2022-08-16 /pmc/articles/PMC9381565/ /pubmed/35974025 http://dx.doi.org/10.1038/s41598-022-17868-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lee, Jihye Kim, Seong Ah Lee, Jiyun Park, Chan Kee Jung, Kyoung In Intereye structure–function relationship using photopic negative response in patients with glaucoma or glaucoma suspect |
title | Intereye structure–function relationship using photopic negative response in patients with glaucoma or glaucoma suspect |
title_full | Intereye structure–function relationship using photopic negative response in patients with glaucoma or glaucoma suspect |
title_fullStr | Intereye structure–function relationship using photopic negative response in patients with glaucoma or glaucoma suspect |
title_full_unstemmed | Intereye structure–function relationship using photopic negative response in patients with glaucoma or glaucoma suspect |
title_short | Intereye structure–function relationship using photopic negative response in patients with glaucoma or glaucoma suspect |
title_sort | intereye structure–function relationship using photopic negative response in patients with glaucoma or glaucoma suspect |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381565/ https://www.ncbi.nlm.nih.gov/pubmed/35974025 http://dx.doi.org/10.1038/s41598-022-17868-8 |
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