HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS

A ‘GGGGCC’ repeat expansion in the first intron of the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The exact mechanism resulting in these neurodegenerative diseases remains elusive, but C9 repeat RNA toxicity has been implic...

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Detalles Bibliográficos
Autores principales: Braems, Elke, Bercier, Valérie, Van Schoor, Evelien, Heeren, Kara, Beckers, Jimmy, Fumagalli, Laura, Dedeene, Lieselot, Moisse, Matthieu, Geudens, Ilse, Hersmus, Nicole, Mehta, Arpan R., Selvaraj, Bhuvaneish T., Chandran, Siddharthan, Ho, Ritchie, Thal, Dietmar R., Van Damme, Philip, Swinnen, Bart, Van Den Bosch, Ludo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381635/
https://www.ncbi.nlm.nih.gov/pubmed/35895140
http://dx.doi.org/10.1007/s00401-022-02471-y

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