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A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration
Adipocyte mitochondrial respiration may influence metabolic fuel partitioning into oxidation versus storage, with implications for whole-body energy expenditure. Although insulin has been shown to influence mitochondrial respiration, the effects of dietary macronutrient composition have not been wel...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381644/ https://www.ncbi.nlm.nih.gov/pubmed/35177807 http://dx.doi.org/10.1038/s41430-022-01097-3 |
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author | Bikman, Benjamin T. Shimy, Kim J. Apovian, Caroline M. Yu, S. Saito, Erin R. Walton, Chase M. Ebbeling, Cara B. Ludwig, David S. |
author_facet | Bikman, Benjamin T. Shimy, Kim J. Apovian, Caroline M. Yu, S. Saito, Erin R. Walton, Chase M. Ebbeling, Cara B. Ludwig, David S. |
author_sort | Bikman, Benjamin T. |
collection | PubMed |
description | Adipocyte mitochondrial respiration may influence metabolic fuel partitioning into oxidation versus storage, with implications for whole-body energy expenditure. Although insulin has been shown to influence mitochondrial respiration, the effects of dietary macronutrient composition have not been well characterized. The aim of this exploratory study was to test the hypothesis that a high-carbohydrate diet lowers the oxygen flux of adipocyte mitochondria ex vivo. Among participants in a randomized-controlled weight-loss maintenance feeding trial, those consuming a high-carbohydrate diet (60% carbohydrate as a proportion of total energy, n = 10) had lower rates of maximal adipose tissue mitochondrial respiration than those consuming a moderate-carbohydrate diet (40%, n = 8, p = 0.039) or a low-carbohydrate diet (20%, n = 9, p = 0.005) after 10 to 15 weeks. This preliminary finding may provide a mechanism for postulated calorie-independent effects of dietary composition on energy expenditure and fat deposition, potentially through the actions of insulin on fuel partitioning. |
format | Online Article Text |
id | pubmed-9381644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-93816442022-09-03 A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration Bikman, Benjamin T. Shimy, Kim J. Apovian, Caroline M. Yu, S. Saito, Erin R. Walton, Chase M. Ebbeling, Cara B. Ludwig, David S. Eur J Clin Nutr Brief Communication Adipocyte mitochondrial respiration may influence metabolic fuel partitioning into oxidation versus storage, with implications for whole-body energy expenditure. Although insulin has been shown to influence mitochondrial respiration, the effects of dietary macronutrient composition have not been well characterized. The aim of this exploratory study was to test the hypothesis that a high-carbohydrate diet lowers the oxygen flux of adipocyte mitochondria ex vivo. Among participants in a randomized-controlled weight-loss maintenance feeding trial, those consuming a high-carbohydrate diet (60% carbohydrate as a proportion of total energy, n = 10) had lower rates of maximal adipose tissue mitochondrial respiration than those consuming a moderate-carbohydrate diet (40%, n = 8, p = 0.039) or a low-carbohydrate diet (20%, n = 9, p = 0.005) after 10 to 15 weeks. This preliminary finding may provide a mechanism for postulated calorie-independent effects of dietary composition on energy expenditure and fat deposition, potentially through the actions of insulin on fuel partitioning. Nature Publishing Group UK 2022-02-17 2022 /pmc/articles/PMC9381644/ /pubmed/35177807 http://dx.doi.org/10.1038/s41430-022-01097-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Brief Communication Bikman, Benjamin T. Shimy, Kim J. Apovian, Caroline M. Yu, S. Saito, Erin R. Walton, Chase M. Ebbeling, Cara B. Ludwig, David S. A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration |
title | A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration |
title_full | A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration |
title_fullStr | A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration |
title_full_unstemmed | A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration |
title_short | A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration |
title_sort | high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381644/ https://www.ncbi.nlm.nih.gov/pubmed/35177807 http://dx.doi.org/10.1038/s41430-022-01097-3 |
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