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Suppression of the necroptotic cell death pathways improves survival in Smn(2B/−) mice

Spinal muscular atrophy (SMA) is a monogenic neuromuscular disease caused by low levels of the Survival Motor Neuron (SMN) protein. Motor neuron degeneration is the central hallmark of the disease. However, the SMN protein is ubiquitously expressed and depletion of the protein in peripheral tissues...

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Detalles Bibliográficos
Autores principales:	Chehade, Lucia, Deguise, Marc-Olivier, De Repentigny, Yves, Yaworski, Rebecca, Beauvais, Ariane, Gagnon, Sabrina, Hensel, Niko, Kothary, Rashmi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381707/ https://www.ncbi.nlm.nih.gov/pubmed/35990890 http://dx.doi.org/10.3389/fncel.2022.972029

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