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Structural features of Dnase1L3 responsible for serum antigen clearance

Autoimmunity develops when extracellular DNA released from dying cells is not cleared from serum. While serum DNA is primarily digested by Dnase1 and Dnase1L3, Dnase1 cannot rescue autoimmunity arising from Dnase1L3 deficiencies. Dnase1L3 uniquely degrades antigenic forms of cell-free DNA, including...

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Detalles Bibliográficos
Autores principales:	McCord, Jon J., Engavale, Minal, Masoumzadeh, Elahe, Villarreal, Johanna, Mapp, Britney, Latham, Michael P., Keyel, Peter A., Sutton, R. Bryan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381713/ https://www.ncbi.nlm.nih.gov/pubmed/35974043 http://dx.doi.org/10.1038/s42003-022-03755-5

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