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EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities

Dysregulation of the epigenome due to alterations in chromatin modifier proteins commonly contribute to malignant transformation. To interrogate the roles of epigenetic modifiers in cancer cells, we generated an epigenome-wide CRISPR-Cas9 knockout library (EPIKOL) that targets a wide-range of epigen...

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Detalles Bibliográficos
Autores principales:	Yedier-Bayram, Ozlem, Gokbayrak, Bengul, Kayabolen, Alisan, Aksu, Ali Cenk, Cavga, Ayse Derya, Cingöz, Ahmet, Kala, Ezgi Yagmur, Karabiyik, Goktug, Günsay, Rauf, Esin, Beril, Morova, Tunc, Uyulur, Fırat, Syed, Hamzah, Philpott, Martin, Cribbs, Adam P., Kung, Sonia H. Y., Lack, Nathan A., Onder, Tamer T., Bagci-Onder, Tugba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381743/ https://www.ncbi.nlm.nih.gov/pubmed/35973998 http://dx.doi.org/10.1038/s41419-022-05146-4

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