Copper starvation induces antimicrobial isocyanide integrated into two distinct biosynthetic pathways in fungi

The genomes of many filamentous fungi, such as Aspergillus spp., include diverse biosynthetic gene clusters of unknown function. We previously showed that low copper levels upregulate a gene cluster that includes crmA, encoding a putative isocyanide synthase. Here we show, using untargeted comparati...

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Detalles Bibliográficos
Autores principales: Won, Tae Hyung, Bok, Jin Woo, Nadig, Nischala, Venkatesh, Nandhitha, Nickles, Grant, Greco, Claudio, Lim, Fang Yun, González, Jennifer B., Turgeon, B. Gillian, Keller, Nancy P., Schroeder, Frank C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381783/
https://www.ncbi.nlm.nih.gov/pubmed/35973982
http://dx.doi.org/10.1038/s41467-022-32394-x

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