Pitavastatin protects against neomycin-induced ototoxicity through inhibition of endoplasmic reticulum stress

Irreversible injury to inner ear hair cells induced by aminoglycoside antibiotics contributes to the formation of sensorineural hearing loss. Pitavastatin (PTV), a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, has been reported to exert neuroprotective effects. However, its role in amin...

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Detalles Bibliográficos
Autores principales: Wu, Yunhao, Meng, Wei, Guan, Ming, Zhao, Xiaolong, Zhang, Chen, Fang, Qiaojun, Zhang, Yuhua, Sun, Zihui, Cai, Mingjing, Huang, Dongdong, Yang, Xuechun, Yu, Yafeng, Cui, Yong, He, Shuangba, Chai, Renjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381809/
https://www.ncbi.nlm.nih.gov/pubmed/35992197
http://dx.doi.org/10.3389/fnmol.2022.963083

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