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PI3K/mTOR inhibitor omipalisib prolongs cardiac repolarization along with a mild proarrhythmic outcome in the AV block dog model

BACKGROUND: The phosphoinositide 3-kinase (PI3K) signaling pathway is an interesting target in cancer treatment. The awareness of the proarrhythmic risk of PI3K inhibitors was raised because PI3K is also involved in regulating signaling toward cardiac ion channels. Canine cardiomyocytes treated with...

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Detalles Bibliográficos
Autores principales:	van Bavel, J. J. A., Pham, C., Beekman, H. D. M., Houtman, M. J. C., Bossu, A., Sparidans, R. W., van der Heyden, M. A. G., Vos, M. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381882/ https://www.ncbi.nlm.nih.gov/pubmed/35990966 http://dx.doi.org/10.3389/fcvm.2022.956538

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