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Application of SHAP values for inferring the optimal functional form of covariates in pharmacokinetic modeling
In population pharmacokinetic (PK) models, interindividual variability is explained by implementation of covariates in the model. The widely used forward stepwise selection method is sensitive to bias, which may lead to an incorrect inclusion of covariates. Alternatives, such as the full fixed effec...
Autores principales: | Janssen, Alexander, Hoogendoorn, Mark, Cnossen, Marjon H., Mathôt, Ron A. A., Cnossen, M. H., Reitsma, S. H., Leebeek, F. W. G., Mathôt, R. A. A., Fijnvandraat, K., Coppens, M., Meijer, K., Schols, S. E. M., Eikenboom, H. C. J., Schutgens, R. E. G., Beckers, E. A. M., Ypma, P., Kruip, M. J. H. A., Polinder, S., Tamminga, R. Y. J., Brons, P., Fischer, K., van Galen, K. P. M., Heubel‐Moenen, F. C. J. I., Nieuwenhuizen, L., Driessens, M. H. E., van Vliet, I., Lock, J., Hazendonk, H. C. A. M., van Moort, I., Heijdra, J. M., Goedhart, M. H. J., Al Arashi, W., Preijers, T., de Jager, N. C. B., Bukkems, L. H., Cloesmeijer, M. E., Janssen, A., Collins, P. W., Liesner, R., Chowdary, P., Millar, C. M., Hart, D., Keeling, D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381890/ http://dx.doi.org/10.1002/psp4.12828 |
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