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DAF‐2/insulin IGF‐1 receptor regulates motility during aging by integrating opposite signaling from muscle and neuronal tissues

During aging, preservation of locomotion is generally considered an indicator of sustained good health, in elderlies and in animal models. In Caenorhabditis elegans, mutants of the insulin‐IGF‐1 receptor DAF2/IIRc represent a paradigm of healthy aging, as their increased lifespan is accompanied by a...

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Detalles Bibliográficos
Autores principales: Roy, Charline, Molin, Laurent, Alcolei, Allan, Solyga, Mathilde, Bonneau, Benjamin, Vachon, Camille, Bessereau, Jean‐Louis, Solari, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381905/
https://www.ncbi.nlm.nih.gov/pubmed/35808897
http://dx.doi.org/10.1111/acel.13660