Multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin

Physiologically‐based pharmacokinetic models combine knowledge about physiology, drug product properties, such as physicochemical parameters, absorption, distribution, metabolism, excretion characteristics, formulation attributes, and trial design or dosing regimen to mechanistically simulate drug p...

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Detalles Bibliográficos
Autores principales: Patel, Nikunjkumar, Clarke, James F., Salem, Farzaneh, Abdulla, Tariq, Martins, Frederico, Arora, Sumit, Tsakalozou, Eleftheria, Hodgkinson, Arran, Arjmandi‐Tash, Omid, Cristea, Sinziana, Ghosh, Priyanka, Alam, Khondoker, Raney, Sam G., Jamei, Masoud, Polak, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381913/
https://www.ncbi.nlm.nih.gov/pubmed/35670226
http://dx.doi.org/10.1002/psp4.12814

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