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Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8 (+) T cells boost cancer cell elimination

A variety of intrinsic and extrinsic factors contribute to the altered efficiency of CTLs in elderly organisms. In particular, the efficacy of antiviral CD8(+) T cells responses in the elderly has come back into focus since the COVID‐19 pandemic outbreak. However, the exact molecular mechanisms lead...

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Detalles Bibliográficos
Autores principales:	Zöphel, Dorina, Angenendt, Adrian, Kaschek, Lea, Ravichandran, Keerthana, Hof, Chantal, Janku, Sandra, Hoth, Markus, Lis, Annette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381916/ https://www.ncbi.nlm.nih.gov/pubmed/35818124 http://dx.doi.org/10.1111/acel.13668

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