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Associations of clinical and circulating metabolic biomarkers with low physical fitness and function in adults with chronic lymphocytic leukemia

Many patients with chronic lymphocytic leukemia (CLL) experience physical dysfunction and low overall fitness. It remains unknown what factors drive CLL physical dysfunction. We assessed physical function and metabolic lipoprotein panels in 106 patients with CLL. In univariate analyses of clinical f...

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Autores principales: Sitlinger, Andrea, Deal, Michael A., Garcia, Erwin, Connelly, Margery, Thompson, Dana, Stewart, Tiffany, Macdonald, Grace, Hanson, Erik D., Neely, Megan, Neely, Ben, Artese, Ashley, Weinberg, J. Brice, Brander, Danielle, Bartlett, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381973/
https://www.ncbi.nlm.nih.gov/pubmed/35992862
http://dx.doi.org/10.3389/fonc.2022.933619
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author Sitlinger, Andrea
Deal, Michael A.
Garcia, Erwin
Connelly, Margery
Thompson, Dana
Stewart, Tiffany
Macdonald, Grace
Hanson, Erik D.
Neely, Megan
Neely, Ben
Artese, Ashley
Weinberg, J. Brice
Brander, Danielle
Bartlett, David B.
author_facet Sitlinger, Andrea
Deal, Michael A.
Garcia, Erwin
Connelly, Margery
Thompson, Dana
Stewart, Tiffany
Macdonald, Grace
Hanson, Erik D.
Neely, Megan
Neely, Ben
Artese, Ashley
Weinberg, J. Brice
Brander, Danielle
Bartlett, David B.
author_sort Sitlinger, Andrea
collection PubMed
description Many patients with chronic lymphocytic leukemia (CLL) experience physical dysfunction and low overall fitness. It remains unknown what factors drive CLL physical dysfunction. We assessed physical function and metabolic lipoprotein panels in 106 patients with CLL. In univariate analyses of clinical factors, a longer time since diagnosis was associated with a higher likelihood of dysfunctional aerobic fitness (OR = 3.56, 95% CI: 1.37–9.22; p = 0.002) and physical performance (SPPB: OR = 2.03, 95% CI: 1.20–3.44; p = 0.004). Having received treatment was associated with a higher likelihood of dysfunctional aerobic fitness (OR = 1.57, 95% CI: 1.02–2.40; p = 0.036), SPPB (OR = 1.85, 95% CI: 1.13–3.03; p = 0.011) and grip strength (OR = 1.67, 95% CI: 1.10–2.55; p = 0.015). We found that several small HDL particle parameters, higher levels of citrate (OR = 2.01, 95% CI: 1.22–3.31; p = 0.030), and lower levels of hemoglobin (OR = 0.50, 95% CI: 0.31–0.82; p = 0.030) were associated with a higher likelihood of dysfunctional aerobic fitness. Multivariable least absolute shrinkage and selection operator (LASSO)-penalized regression analyses using variable importance measures (VIM) showed that 7.8-nm HDL particles (VIM = 1.000) and total HDL particle levels (VIM = 1.000) were more informative than clinical measures for the odds of dysfunctional aerobic fitness and 6-min walk functional fitness, respectively, while 10.3-nm HDL particles (VIM = 0.383) were more informative for grip strength. Time since diagnosis (VIM = 0.680) and having received treatment (VIM = 0.490) were more informative than lipoprotein measures for the odds of having dysfunctional SPPB. Taken together, we establish significant relationships between clinical and metabolic factors and physical characteristics that might prompt early use of ancillary support services.
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spelling pubmed-93819732022-08-18 Associations of clinical and circulating metabolic biomarkers with low physical fitness and function in adults with chronic lymphocytic leukemia Sitlinger, Andrea Deal, Michael A. Garcia, Erwin Connelly, Margery Thompson, Dana Stewart, Tiffany Macdonald, Grace Hanson, Erik D. Neely, Megan Neely, Ben Artese, Ashley Weinberg, J. Brice Brander, Danielle Bartlett, David B. Front Oncol Oncology Many patients with chronic lymphocytic leukemia (CLL) experience physical dysfunction and low overall fitness. It remains unknown what factors drive CLL physical dysfunction. We assessed physical function and metabolic lipoprotein panels in 106 patients with CLL. In univariate analyses of clinical factors, a longer time since diagnosis was associated with a higher likelihood of dysfunctional aerobic fitness (OR = 3.56, 95% CI: 1.37–9.22; p = 0.002) and physical performance (SPPB: OR = 2.03, 95% CI: 1.20–3.44; p = 0.004). Having received treatment was associated with a higher likelihood of dysfunctional aerobic fitness (OR = 1.57, 95% CI: 1.02–2.40; p = 0.036), SPPB (OR = 1.85, 95% CI: 1.13–3.03; p = 0.011) and grip strength (OR = 1.67, 95% CI: 1.10–2.55; p = 0.015). We found that several small HDL particle parameters, higher levels of citrate (OR = 2.01, 95% CI: 1.22–3.31; p = 0.030), and lower levels of hemoglobin (OR = 0.50, 95% CI: 0.31–0.82; p = 0.030) were associated with a higher likelihood of dysfunctional aerobic fitness. Multivariable least absolute shrinkage and selection operator (LASSO)-penalized regression analyses using variable importance measures (VIM) showed that 7.8-nm HDL particles (VIM = 1.000) and total HDL particle levels (VIM = 1.000) were more informative than clinical measures for the odds of dysfunctional aerobic fitness and 6-min walk functional fitness, respectively, while 10.3-nm HDL particles (VIM = 0.383) were more informative for grip strength. Time since diagnosis (VIM = 0.680) and having received treatment (VIM = 0.490) were more informative than lipoprotein measures for the odds of having dysfunctional SPPB. Taken together, we establish significant relationships between clinical and metabolic factors and physical characteristics that might prompt early use of ancillary support services. Frontiers Media S.A. 2022-08-03 /pmc/articles/PMC9381973/ /pubmed/35992862 http://dx.doi.org/10.3389/fonc.2022.933619 Text en Copyright © 2022 Sitlinger, Deal, Garcia, Connelly, Thompson, Stewart, Macdonald, Hanson, Neely, Neely, Artese, Weinberg, Brander and Bartlett https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Sitlinger, Andrea
Deal, Michael A.
Garcia, Erwin
Connelly, Margery
Thompson, Dana
Stewart, Tiffany
Macdonald, Grace
Hanson, Erik D.
Neely, Megan
Neely, Ben
Artese, Ashley
Weinberg, J. Brice
Brander, Danielle
Bartlett, David B.
Associations of clinical and circulating metabolic biomarkers with low physical fitness and function in adults with chronic lymphocytic leukemia
title Associations of clinical and circulating metabolic biomarkers with low physical fitness and function in adults with chronic lymphocytic leukemia
title_full Associations of clinical and circulating metabolic biomarkers with low physical fitness and function in adults with chronic lymphocytic leukemia
title_fullStr Associations of clinical and circulating metabolic biomarkers with low physical fitness and function in adults with chronic lymphocytic leukemia
title_full_unstemmed Associations of clinical and circulating metabolic biomarkers with low physical fitness and function in adults with chronic lymphocytic leukemia
title_short Associations of clinical and circulating metabolic biomarkers with low physical fitness and function in adults with chronic lymphocytic leukemia
title_sort associations of clinical and circulating metabolic biomarkers with low physical fitness and function in adults with chronic lymphocytic leukemia
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381973/
https://www.ncbi.nlm.nih.gov/pubmed/35992862
http://dx.doi.org/10.3389/fonc.2022.933619
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