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Alteration of brain functional networks induced by electroacupuncture stimulation in rats with ischemia–reperfusion: An independent component analysis

Motor dysfunction is the major sequela of ischemic stroke. Motor recovery after stroke has been shown to be associated with remodeling of large-scale brain networks, both functionally and structurally. Electroacupuncture (EA) is a traditional Chinese medicine application that has frequently been rec...

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Autores principales: Li, Si-Si, Xing, Xiang-Xin, Hua, Xu-Yun, Zhang, Yu-Wen, Wu, Jia-Jia, Shan, Chun-Lei, Zheng, Mou-Xiong, Wang, He, Xu, Jian-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382119/
https://www.ncbi.nlm.nih.gov/pubmed/35992929
http://dx.doi.org/10.3389/fnins.2022.958804
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author Li, Si-Si
Xing, Xiang-Xin
Hua, Xu-Yun
Zhang, Yu-Wen
Wu, Jia-Jia
Shan, Chun-Lei
Zheng, Mou-Xiong
Wang, He
Xu, Jian-Guang
author_facet Li, Si-Si
Xing, Xiang-Xin
Hua, Xu-Yun
Zhang, Yu-Wen
Wu, Jia-Jia
Shan, Chun-Lei
Zheng, Mou-Xiong
Wang, He
Xu, Jian-Guang
author_sort Li, Si-Si
collection PubMed
description Motor dysfunction is the major sequela of ischemic stroke. Motor recovery after stroke has been shown to be associated with remodeling of large-scale brain networks, both functionally and structurally. Electroacupuncture (EA) is a traditional Chinese medicine application that has frequently been recommended as an alternative therapy for ischemic stroke and is reportedly effective for alleviating motor symptoms in patients. In the present study, the effect of EA on the alterations of functional resting state networks (RSNs) was explored after middle cerebral artery occlusion/reperfusion (MCAO/R) injury using resting-state functional MRI. Rats were randomly assigned to three groups, including the sham group, MCAO/R group and MCAO/R+EA group. The ladder rung walking test was conducted prior to and after modeling to assess behavioral changes. RSNs were identified based on the independent component analysis (ICA) performed on the fMRI data from groups. EA treatment effectively reduced the occurrence of contralateral forelimb foot faults. Furthermore, our results suggested the disrupted function of the whole-brain network following ischemic stroke and the modulatory effect of acupuncture. The sensorimotor network (SMN), interoceptive network (IN), default mode network (DMN) and salience network (SN) were related to the therapeutic effect of EA on stroke recovery. Collectively, our findings confirmed the effect of EA on motor function recovery after cerebral ischemia reperfusion and shed light on the assessment of EA intervention-induced effects on brain networks. This study provides neuroimaging evidence to explain the therapeutic effects of EA in ischemic stroke and will lay the groundwork for further studies.
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spelling pubmed-93821192022-08-18 Alteration of brain functional networks induced by electroacupuncture stimulation in rats with ischemia–reperfusion: An independent component analysis Li, Si-Si Xing, Xiang-Xin Hua, Xu-Yun Zhang, Yu-Wen Wu, Jia-Jia Shan, Chun-Lei Zheng, Mou-Xiong Wang, He Xu, Jian-Guang Front Neurosci Neuroscience Motor dysfunction is the major sequela of ischemic stroke. Motor recovery after stroke has been shown to be associated with remodeling of large-scale brain networks, both functionally and structurally. Electroacupuncture (EA) is a traditional Chinese medicine application that has frequently been recommended as an alternative therapy for ischemic stroke and is reportedly effective for alleviating motor symptoms in patients. In the present study, the effect of EA on the alterations of functional resting state networks (RSNs) was explored after middle cerebral artery occlusion/reperfusion (MCAO/R) injury using resting-state functional MRI. Rats were randomly assigned to three groups, including the sham group, MCAO/R group and MCAO/R+EA group. The ladder rung walking test was conducted prior to and after modeling to assess behavioral changes. RSNs were identified based on the independent component analysis (ICA) performed on the fMRI data from groups. EA treatment effectively reduced the occurrence of contralateral forelimb foot faults. Furthermore, our results suggested the disrupted function of the whole-brain network following ischemic stroke and the modulatory effect of acupuncture. The sensorimotor network (SMN), interoceptive network (IN), default mode network (DMN) and salience network (SN) were related to the therapeutic effect of EA on stroke recovery. Collectively, our findings confirmed the effect of EA on motor function recovery after cerebral ischemia reperfusion and shed light on the assessment of EA intervention-induced effects on brain networks. This study provides neuroimaging evidence to explain the therapeutic effects of EA in ischemic stroke and will lay the groundwork for further studies. Frontiers Media S.A. 2022-08-03 /pmc/articles/PMC9382119/ /pubmed/35992929 http://dx.doi.org/10.3389/fnins.2022.958804 Text en Copyright © 2022 Li, Xing, Hua, Zhang, Wu, Shan, Zheng, Wang and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Li, Si-Si
Xing, Xiang-Xin
Hua, Xu-Yun
Zhang, Yu-Wen
Wu, Jia-Jia
Shan, Chun-Lei
Zheng, Mou-Xiong
Wang, He
Xu, Jian-Guang
Alteration of brain functional networks induced by electroacupuncture stimulation in rats with ischemia–reperfusion: An independent component analysis
title Alteration of brain functional networks induced by electroacupuncture stimulation in rats with ischemia–reperfusion: An independent component analysis
title_full Alteration of brain functional networks induced by electroacupuncture stimulation in rats with ischemia–reperfusion: An independent component analysis
title_fullStr Alteration of brain functional networks induced by electroacupuncture stimulation in rats with ischemia–reperfusion: An independent component analysis
title_full_unstemmed Alteration of brain functional networks induced by electroacupuncture stimulation in rats with ischemia–reperfusion: An independent component analysis
title_short Alteration of brain functional networks induced by electroacupuncture stimulation in rats with ischemia–reperfusion: An independent component analysis
title_sort alteration of brain functional networks induced by electroacupuncture stimulation in rats with ischemia–reperfusion: an independent component analysis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382119/
https://www.ncbi.nlm.nih.gov/pubmed/35992929
http://dx.doi.org/10.3389/fnins.2022.958804
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