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Pan-cancer landscape of T-cell exhaustion heterogeneity within the tumor microenvironment revealed a progressive roadmap of hierarchical dysfunction associated with prognosis and therapeutic efficacy

BACKGROUND: T cells form the major component of anti-tumor immunity. A deeper understanding of T cell exhaustion (TEX) heterogeneity within the tumor microenvironment (TME) is key to overcoming TEX and improving checkpoint blockade immunotherapies in the clinical setting. METHODS: We conducted a com...

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Detalles Bibliográficos
Autores principales:	Zhang, Zicheng, Chen, Lu, Chen, Hongyan, Zhao, Jingting, Li, Ke, Sun, Jie, Zhou, Meng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382263/ https://www.ncbi.nlm.nih.gov/pubmed/35961204 http://dx.doi.org/10.1016/j.ebiom.2022.104207

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