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Multifaceted role of RNA editing in promoting loss-of-function of PODXL in cancer

PODXL, a protein that is dysregulated in multiple cancers, plays an important role in promoting cancer metastasis. In this study, we report that RNA editing promotes the inclusion of a PODXL alternative exon. The resulting edited PODXL long isoform is more prone to protease digestion and has the str...

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Detalles Bibliográficos
Autores principales:	Fu, Ting, Chan, Tracey W., Bahn, Jae Hoon, Kim, Tae-Hyung, Rowat, Amy C., Xiao, Xinshu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382340/ https://www.ncbi.nlm.nih.gov/pubmed/35992085 http://dx.doi.org/10.1016/j.isci.2022.104836

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