AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness

The transduction of acoustic information by hair cells depends upon mechanosensitive stereociliary bundles that project from their apical surface. Mutations or absence of the stereociliary protein EPS8 cause deafness in humans and mice, respectively. Eps8 knockout mice (Eps8(−/−)) have hair cells wi...

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Detalles Bibliográficos
Autores principales: Jeng, Jing-Yi, Carlton, Adam J., Goodyear, Richard J., Chinowsky, Colbie, Ceriani, Federico, Johnson, Stuart L., Sung, Tsung-Chang, Dayn, Yelena, Richardson, Guy P., Bowl, Michael R., Brown, Steve D.M., Manor, Uri, Marcotti, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382420/
https://www.ncbi.nlm.nih.gov/pubmed/36034774
http://dx.doi.org/10.1016/j.omtm.2022.07.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382420/
https://www.ncbi.nlm.nih.gov/pubmed/36034774
http://dx.doi.org/10.1016/j.omtm.2022.07.012

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