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Overview of non-coding RNAs in breast cancers

Breast cancer in women is the second most common cancer and the fifth leading cause of cancer death worldwide. Although earlier diagnosis and detection of breast cancer has resulted in lower mortality rates, further advances in prevention, detection, and treatment are needed to improve outcomes and...

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Detalles Bibliográficos
Autores principales: Dabi, Yohann, Bendifallah, Sofiane, Suisse, Stéphane, Haury, Julie, Touboul, Cyril, Puchar, Anne, Favier, Amélia, Daraï, Emile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382556/
https://www.ncbi.nlm.nih.gov/pubmed/35961269
http://dx.doi.org/10.1016/j.tranon.2022.101512
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author Dabi, Yohann
Bendifallah, Sofiane
Suisse, Stéphane
Haury, Julie
Touboul, Cyril
Puchar, Anne
Favier, Amélia
Daraï, Emile
author_facet Dabi, Yohann
Bendifallah, Sofiane
Suisse, Stéphane
Haury, Julie
Touboul, Cyril
Puchar, Anne
Favier, Amélia
Daraï, Emile
author_sort Dabi, Yohann
collection PubMed
description Breast cancer in women is the second most common cancer and the fifth leading cause of cancer death worldwide. Although earlier diagnosis and detection of breast cancer has resulted in lower mortality rates, further advances in prevention, detection, and treatment are needed to improve outcomes and survival for women with breast cancer as well as to offer a personalized therapeutic approach. It is now well-established that non-coding RNAs (ncRNAs) represent 98% of the transcriptome but in-depth knowledge about their involvement in the regulation of gene expression is lacking. A growing body of research indicates that ncRNAs are essential for tumorigenesis by regulating the expression of tumour-related genes. In this review, we focus on their implication in breast cancer genesis but also report the latest knowledge of their theragnostic and therapeutic role. We highlight the need for accurate quantification of circulating ncRNAs which is determinant to develop reliable biomarkers. Further studies are mandatory to finally enter the era of personalized medicine for women with breast cancer.
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spelling pubmed-93825562022-08-24 Overview of non-coding RNAs in breast cancers Dabi, Yohann Bendifallah, Sofiane Suisse, Stéphane Haury, Julie Touboul, Cyril Puchar, Anne Favier, Amélia Daraï, Emile Transl Oncol Review Breast cancer in women is the second most common cancer and the fifth leading cause of cancer death worldwide. Although earlier diagnosis and detection of breast cancer has resulted in lower mortality rates, further advances in prevention, detection, and treatment are needed to improve outcomes and survival for women with breast cancer as well as to offer a personalized therapeutic approach. It is now well-established that non-coding RNAs (ncRNAs) represent 98% of the transcriptome but in-depth knowledge about their involvement in the regulation of gene expression is lacking. A growing body of research indicates that ncRNAs are essential for tumorigenesis by regulating the expression of tumour-related genes. In this review, we focus on their implication in breast cancer genesis but also report the latest knowledge of their theragnostic and therapeutic role. We highlight the need for accurate quantification of circulating ncRNAs which is determinant to develop reliable biomarkers. Further studies are mandatory to finally enter the era of personalized medicine for women with breast cancer. Neoplasia Press 2022-08-09 /pmc/articles/PMC9382556/ /pubmed/35961269 http://dx.doi.org/10.1016/j.tranon.2022.101512 Text en © 2022 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Dabi, Yohann
Bendifallah, Sofiane
Suisse, Stéphane
Haury, Julie
Touboul, Cyril
Puchar, Anne
Favier, Amélia
Daraï, Emile
Overview of non-coding RNAs in breast cancers
title Overview of non-coding RNAs in breast cancers
title_full Overview of non-coding RNAs in breast cancers
title_fullStr Overview of non-coding RNAs in breast cancers
title_full_unstemmed Overview of non-coding RNAs in breast cancers
title_short Overview of non-coding RNAs in breast cancers
title_sort overview of non-coding rnas in breast cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382556/
https://www.ncbi.nlm.nih.gov/pubmed/35961269
http://dx.doi.org/10.1016/j.tranon.2022.101512
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