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Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa
Malaria has been hypothesized as a factor that may have reduced the severity of the COVID-19 pandemic in sub-Saharan Africa. To evaluate the effect of recent malaria on COVID-19 we assessed a subgroup of individuals participating in a longitudinal cohort COVID-19 serosurvey that were also undergoing...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382593/ https://www.ncbi.nlm.nih.gov/pubmed/35990648 http://dx.doi.org/10.3389/fimmu.2022.959697 |
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author | Woodford, John Sagara, Issaka Diawara, Halimatou Assadou, Mahamadoun Hamady Katile, Abdoulaye Attaher, Oumar Issiaka, Djibrilla Santara, Gaoussou Soumbounou, Ibrahim H. Traore, Seydou Traore, Moussa Dicko, Oumar M. Niambele, Sidi Mohamed Mahamar, Almahamoudou Kamate, Bourama Haidara, Bayaya Sissoko, Kourane Sankare, Seydou Diarra, Sadio dite Koni Zeguime, Amatigue Doritchamou, Justin Y. A. Zaidi, Irfan Dicko, Alassane Duffy, Patrick E. |
author_facet | Woodford, John Sagara, Issaka Diawara, Halimatou Assadou, Mahamadoun Hamady Katile, Abdoulaye Attaher, Oumar Issiaka, Djibrilla Santara, Gaoussou Soumbounou, Ibrahim H. Traore, Seydou Traore, Moussa Dicko, Oumar M. Niambele, Sidi Mohamed Mahamar, Almahamoudou Kamate, Bourama Haidara, Bayaya Sissoko, Kourane Sankare, Seydou Diarra, Sadio dite Koni Zeguime, Amatigue Doritchamou, Justin Y. A. Zaidi, Irfan Dicko, Alassane Duffy, Patrick E. |
author_sort | Woodford, John |
collection | PubMed |
description | Malaria has been hypothesized as a factor that may have reduced the severity of the COVID-19 pandemic in sub-Saharan Africa. To evaluate the effect of recent malaria on COVID-19 we assessed a subgroup of individuals participating in a longitudinal cohort COVID-19 serosurvey that were also undergoing intensive malaria monitoring as part of antimalarial vaccine trials during the 2020 transmission season in Mali. These communities experienced a high incidence of primarily asymptomatic or mild COVID-19 during 2020 and 2021. In 1314 individuals, 711 were parasitemic during the 2020 malaria transmission season; 442 were symptomatic with clinical malaria and 269 had asymptomatic infection. Presence of parasitemia was not associated with new COVID-19 seroconversion (29.7% (211/711) vs. 30.0% (181/603), p=0.9038) or with rates of reported symptomatic seroconversion during the malaria transmission season. In the subsequent dry season, prior parasitemia was not associated with new COVID-19 seroconversion (30.2% (133/441) vs. 31.2% (108/346), p=0.7499), with symptomatic seroconversion, or with reversion from seropositive to seronegative (prior parasitemia: 36.2% (64/177) vs. no parasitemia: 30.1% (37/119), p=0.3842). After excluding participants with asymptomatic infection, clinical malaria was also not associated with COVID-19 serostatus or symptomatic seroconversion when compared to participants with no parasitemia during the monitoring period. In communities with intense seasonal malaria and a high incidence of asymptomatic or mild COVID-19, we did not demonstrate a relationship between recent malaria and subsequent response to COVID-19. Lifetime exposure, rather than recent infection, may be responsible for any effect of malaria on COVID-19 severity. |
format | Online Article Text |
id | pubmed-9382593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93825932022-08-18 Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa Woodford, John Sagara, Issaka Diawara, Halimatou Assadou, Mahamadoun Hamady Katile, Abdoulaye Attaher, Oumar Issiaka, Djibrilla Santara, Gaoussou Soumbounou, Ibrahim H. Traore, Seydou Traore, Moussa Dicko, Oumar M. Niambele, Sidi Mohamed Mahamar, Almahamoudou Kamate, Bourama Haidara, Bayaya Sissoko, Kourane Sankare, Seydou Diarra, Sadio dite Koni Zeguime, Amatigue Doritchamou, Justin Y. A. Zaidi, Irfan Dicko, Alassane Duffy, Patrick E. Front Immunol Immunology Malaria has been hypothesized as a factor that may have reduced the severity of the COVID-19 pandemic in sub-Saharan Africa. To evaluate the effect of recent malaria on COVID-19 we assessed a subgroup of individuals participating in a longitudinal cohort COVID-19 serosurvey that were also undergoing intensive malaria monitoring as part of antimalarial vaccine trials during the 2020 transmission season in Mali. These communities experienced a high incidence of primarily asymptomatic or mild COVID-19 during 2020 and 2021. In 1314 individuals, 711 were parasitemic during the 2020 malaria transmission season; 442 were symptomatic with clinical malaria and 269 had asymptomatic infection. Presence of parasitemia was not associated with new COVID-19 seroconversion (29.7% (211/711) vs. 30.0% (181/603), p=0.9038) or with rates of reported symptomatic seroconversion during the malaria transmission season. In the subsequent dry season, prior parasitemia was not associated with new COVID-19 seroconversion (30.2% (133/441) vs. 31.2% (108/346), p=0.7499), with symptomatic seroconversion, or with reversion from seropositive to seronegative (prior parasitemia: 36.2% (64/177) vs. no parasitemia: 30.1% (37/119), p=0.3842). After excluding participants with asymptomatic infection, clinical malaria was also not associated with COVID-19 serostatus or symptomatic seroconversion when compared to participants with no parasitemia during the monitoring period. In communities with intense seasonal malaria and a high incidence of asymptomatic or mild COVID-19, we did not demonstrate a relationship between recent malaria and subsequent response to COVID-19. Lifetime exposure, rather than recent infection, may be responsible for any effect of malaria on COVID-19 severity. Frontiers Media S.A. 2022-08-03 /pmc/articles/PMC9382593/ /pubmed/35990648 http://dx.doi.org/10.3389/fimmu.2022.959697 Text en Copyright © 2022 Woodford, Sagara, Diawara, Assadou, Katile, Attaher, Issiaka, Santara, Soumbounou, Traore, Traore, Dicko, Niambele, Mahamar, Kamate, Haidara, Sissoko, Sankare, Diarra, Zeguime, Doritchamou, Zaidi, Dicko and Duffy https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Woodford, John Sagara, Issaka Diawara, Halimatou Assadou, Mahamadoun Hamady Katile, Abdoulaye Attaher, Oumar Issiaka, Djibrilla Santara, Gaoussou Soumbounou, Ibrahim H. Traore, Seydou Traore, Moussa Dicko, Oumar M. Niambele, Sidi Mohamed Mahamar, Almahamoudou Kamate, Bourama Haidara, Bayaya Sissoko, Kourane Sankare, Seydou Diarra, Sadio dite Koni Zeguime, Amatigue Doritchamou, Justin Y. A. Zaidi, Irfan Dicko, Alassane Duffy, Patrick E. Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa |
title | Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa |
title_full | Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa |
title_fullStr | Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa |
title_full_unstemmed | Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa |
title_short | Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa |
title_sort | recent malaria does not substantially impact covid-19 antibody response or rates of symptomatic illness in communities with high malaria and covid-19 transmission in mali, west africa |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382593/ https://www.ncbi.nlm.nih.gov/pubmed/35990648 http://dx.doi.org/10.3389/fimmu.2022.959697 |
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