Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion protein

Both T cells and B cells have been shown to be generated after infection with SARS-CoV-2 yet protocols or experimental models to study one or the other are less common. Here, we generate a chimeric protein (SpiN) that comprises the receptor binding domain (RBD) from Spike (S) and the nucleocapsid (N...

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Detalles Bibliográficos
Autores principales: Castro, Julia T., Azevedo, Patrick, Fumagalli, Marcílio J., Hojo-Souza, Natalia S., Salazar, Natalia, Almeida, Gregório G., Oliveira, Livia I., Faustino, Lídia, Antonelli, Lis R., Marçal, Tomas G., Augusto, Marconi, Valiate, Bruno, Fiorini, Alex, Rattis, Bruna, Ramos, Simone G., Piccin, Mariela, Nonato, Osvaldo Campos, Benevides, Luciana, Magalhães, Rubens, Cassaro, Bruno, Burle, Gabriela, Doro, Daniel, Kalil, Jorge, Durigon, Edson, Salazar, Andrés, Caballero, Otávia, Santiago, Helton, Machado, Alexandre, Silva, João S., da Fonseca, Flávio, Fernandes, Ana Paula, Teixeira, Santuza R., Gazzinelli, Ricardo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382605/
https://www.ncbi.nlm.nih.gov/pubmed/35977933
http://dx.doi.org/10.1038/s41467-022-32547-y

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