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C–C chemokine receptor 5 and acute graft‐versus‐host disease
BACKGROUND: The C–C chemokine receptor 5 (CCR5) is mainly expressed in a variety of immune cells. It interacts with multiple chemokine ligands that mediate the trafficking and recruitment of effector cells toward sites of inflammation. CCR5 not only plays a critical role in cell growth, activation,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382859/ https://www.ncbi.nlm.nih.gov/pubmed/36039647 http://dx.doi.org/10.1002/iid3.687 |
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author | Yuan, Jing Ren, Han‐yun |
author_facet | Yuan, Jing Ren, Han‐yun |
author_sort | Yuan, Jing |
collection | PubMed |
description | BACKGROUND: The C–C chemokine receptor 5 (CCR5) is mainly expressed in a variety of immune cells. It interacts with multiple chemokine ligands that mediate the trafficking and recruitment of effector cells toward sites of inflammation. CCR5 not only plays a critical role in cell growth, activation, differentiation, adhesion, and migration but also participates in the development of acute graft‐versus‐host disease (GVHD) after allogeneic hematopoietic cell transplantation. METHODS: This is a literature review article. The research design method is an evidence‐based rapid review. The present discourse aim is first to scrutinize and assess the available literature on CCR5 and acute GVHD. Standard literature and database searches were implemented, gathered relevant material, and extracted information was then assessed. RESULTS: CCR5 is a marker of GVHD effector cells, and CCR5 expression is elevated when acute GVHD occurs. CCR5 blockade with maraviroc in clinical trials results in a low incidence of acute GVHD. The immune mechanism includes that CCR5 blockade inhibits donor T cell migration and recruitment toward target organs, reduces the absolute numbers of donor T cells, is capable of slightly suppressing dendritic cell maturation, and reduces the percentage of Th1 and Th17 subsets. CCR5 blockade also inhibits internalization and activation of chemokines, inhibits proliferation and chemotaxis of T cells, and decreases the production of TNF‐α and IFN‐γ. In addition, there may be a form of crosstalk between CCR5 and CCR2. Inconsistently, infusion of CCR5(−/−) Tregs into lethally irradiated mice significantly increased the infiltration of CD4(+) and CD8(+) T cells into the liver, resulting in earlier and more severe GVHD. CONCLUSION: This review indicates that CCR5 plays an important role in pathogenesis and development of acute GVHD. Elucidating its role in different immune cells will aid the development of targeted therapeutic treatments. |
format | Online Article Text |
id | pubmed-9382859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93828592022-08-19 C–C chemokine receptor 5 and acute graft‐versus‐host disease Yuan, Jing Ren, Han‐yun Immun Inflamm Dis Review Article BACKGROUND: The C–C chemokine receptor 5 (CCR5) is mainly expressed in a variety of immune cells. It interacts with multiple chemokine ligands that mediate the trafficking and recruitment of effector cells toward sites of inflammation. CCR5 not only plays a critical role in cell growth, activation, differentiation, adhesion, and migration but also participates in the development of acute graft‐versus‐host disease (GVHD) after allogeneic hematopoietic cell transplantation. METHODS: This is a literature review article. The research design method is an evidence‐based rapid review. The present discourse aim is first to scrutinize and assess the available literature on CCR5 and acute GVHD. Standard literature and database searches were implemented, gathered relevant material, and extracted information was then assessed. RESULTS: CCR5 is a marker of GVHD effector cells, and CCR5 expression is elevated when acute GVHD occurs. CCR5 blockade with maraviroc in clinical trials results in a low incidence of acute GVHD. The immune mechanism includes that CCR5 blockade inhibits donor T cell migration and recruitment toward target organs, reduces the absolute numbers of donor T cells, is capable of slightly suppressing dendritic cell maturation, and reduces the percentage of Th1 and Th17 subsets. CCR5 blockade also inhibits internalization and activation of chemokines, inhibits proliferation and chemotaxis of T cells, and decreases the production of TNF‐α and IFN‐γ. In addition, there may be a form of crosstalk between CCR5 and CCR2. Inconsistently, infusion of CCR5(−/−) Tregs into lethally irradiated mice significantly increased the infiltration of CD4(+) and CD8(+) T cells into the liver, resulting in earlier and more severe GVHD. CONCLUSION: This review indicates that CCR5 plays an important role in pathogenesis and development of acute GVHD. Elucidating its role in different immune cells will aid the development of targeted therapeutic treatments. John Wiley and Sons Inc. 2022-08-17 /pmc/articles/PMC9382859/ /pubmed/36039647 http://dx.doi.org/10.1002/iid3.687 Text en © 2022 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yuan, Jing Ren, Han‐yun C–C chemokine receptor 5 and acute graft‐versus‐host disease |
title | C–C chemokine receptor 5 and acute graft‐versus‐host disease |
title_full | C–C chemokine receptor 5 and acute graft‐versus‐host disease |
title_fullStr | C–C chemokine receptor 5 and acute graft‐versus‐host disease |
title_full_unstemmed | C–C chemokine receptor 5 and acute graft‐versus‐host disease |
title_short | C–C chemokine receptor 5 and acute graft‐versus‐host disease |
title_sort | c–c chemokine receptor 5 and acute graft‐versus‐host disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382859/ https://www.ncbi.nlm.nih.gov/pubmed/36039647 http://dx.doi.org/10.1002/iid3.687 |
work_keys_str_mv | AT yuanjing ccchemokinereceptor5andacutegraftversushostdisease AT renhanyun ccchemokinereceptor5andacutegraftversushostdisease |