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Clinical Implication of Genetic Testing in Dilated Cardiomyopathy

Dilated cardiomyopathy (DCM) is one of the important causes of heart failure (HF). With the rapidly evolving technologies for gene analysis and tremendous advances in knowledge of HF genetics, the importance of genetic testing in DCM is currently highlighted. Several genetic variants causing DCM hav...

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Autores principales: Lee, Ju-Hee, Lee, Sang Eun, Cho, Myeong-Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Heart Failure 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9383343/
https://www.ncbi.nlm.nih.gov/pubmed/36262197
http://dx.doi.org/10.36628/ijhf.2021.0024
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author Lee, Ju-Hee
Lee, Sang Eun
Cho, Myeong-Chan
author_facet Lee, Ju-Hee
Lee, Sang Eun
Cho, Myeong-Chan
author_sort Lee, Ju-Hee
collection PubMed
description Dilated cardiomyopathy (DCM) is one of the important causes of heart failure (HF). With the rapidly evolving technologies for gene analysis and tremendous advances in knowledge of HF genetics, the importance of genetic testing in DCM is currently highlighted. Several genetic variants causing DCM have been identified and this information is used for diagnosis, risk stratification and family screening of DCM patients. However, there are still several challenges in applying genetic testing to real clinical practice. In this review, we will summarize recent understandings in DCM genetics and provide an evidence-based practical guide to the use of genetic testing for DCM patients.
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spelling pubmed-93833432022-10-18 Clinical Implication of Genetic Testing in Dilated Cardiomyopathy Lee, Ju-Hee Lee, Sang Eun Cho, Myeong-Chan Int J Heart Fail Review Article Dilated cardiomyopathy (DCM) is one of the important causes of heart failure (HF). With the rapidly evolving technologies for gene analysis and tremendous advances in knowledge of HF genetics, the importance of genetic testing in DCM is currently highlighted. Several genetic variants causing DCM have been identified and this information is used for diagnosis, risk stratification and family screening of DCM patients. However, there are still several challenges in applying genetic testing to real clinical practice. In this review, we will summarize recent understandings in DCM genetics and provide an evidence-based practical guide to the use of genetic testing for DCM patients. Korean Society of Heart Failure 2021-10-21 /pmc/articles/PMC9383343/ /pubmed/36262197 http://dx.doi.org/10.36628/ijhf.2021.0024 Text en Copyright © 2022. Korean Society of Heart Failure https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lee, Ju-Hee
Lee, Sang Eun
Cho, Myeong-Chan
Clinical Implication of Genetic Testing in Dilated Cardiomyopathy
title Clinical Implication of Genetic Testing in Dilated Cardiomyopathy
title_full Clinical Implication of Genetic Testing in Dilated Cardiomyopathy
title_fullStr Clinical Implication of Genetic Testing in Dilated Cardiomyopathy
title_full_unstemmed Clinical Implication of Genetic Testing in Dilated Cardiomyopathy
title_short Clinical Implication of Genetic Testing in Dilated Cardiomyopathy
title_sort clinical implication of genetic testing in dilated cardiomyopathy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9383343/
https://www.ncbi.nlm.nih.gov/pubmed/36262197
http://dx.doi.org/10.36628/ijhf.2021.0024
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