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Prognostic Value of Short-Term Follow-up of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design
Several surrogate biomarkers possess prognostic significance for heart failure (HF), and a decline in their respective values may predict clinical improvement. However, data on the prognostic value of these biomarkers during short-term follow-up after discharge in acute decompensated HF are scarce....
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Heart Failure
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9383348/ https://www.ncbi.nlm.nih.gov/pubmed/36263107 http://dx.doi.org/10.36628/ijhf.2022.0005 |
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author | Cho, Dong-Hyuk Son, Jung-Woo Lee, Chan Joo Choi, Jimi Kim, Mi-Na Lee, Ju-Hee Lee, Sunki Yang, Dong Heon Cho, Hyun-Jai Choi, Jin-Oh Kim, Eung Ju Choi, Dong-Ju Yoo, Byung-Su |
author_facet | Cho, Dong-Hyuk Son, Jung-Woo Lee, Chan Joo Choi, Jimi Kim, Mi-Na Lee, Ju-Hee Lee, Sunki Yang, Dong Heon Cho, Hyun-Jai Choi, Jin-Oh Kim, Eung Ju Choi, Dong-Ju Yoo, Byung-Su |
author_sort | Cho, Dong-Hyuk |
collection | PubMed |
description | Several surrogate biomarkers possess prognostic significance for heart failure (HF), and a decline in their respective values may predict clinical improvement. However, data on the prognostic value of these biomarkers during short-term follow-up after discharge in acute decompensated HF are scarce. We aim to evaluate the prognostic value of short-term follow-up of surrogate biomarkers for predicting the prognosis of hospitalized patients with acute decompensated HF. This multi-center, prospective study will enroll consecutive hospitalized patients with acute decompensated HF. All patients will undergo sampling and comparison of biomarkers, including plasma N-terminal pro-brain natriuretic peptide, growth differentiation factor 15, troponin-T, high-sensitivity C-reactive protein, and urinary albumin/creatinine ratio obtained within 1 month and 6 months after discharge from the index admission. The primary endpoint is a composite of cardiovascular mortality or HF hospitalization during 1 year of follow-up. We will investigate the prognostic value of multiple biomarkers for the primary endpoint. This trial will provide robust evidence for novel multi-biomarker strategies for acute decompensated HF in real-world settings. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04437628 |
format | Online Article Text |
id | pubmed-9383348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Society of Heart Failure |
record_format | MEDLINE/PubMed |
spelling | pubmed-93833482022-10-18 Prognostic Value of Short-Term Follow-up of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design Cho, Dong-Hyuk Son, Jung-Woo Lee, Chan Joo Choi, Jimi Kim, Mi-Na Lee, Ju-Hee Lee, Sunki Yang, Dong Heon Cho, Hyun-Jai Choi, Jin-Oh Kim, Eung Ju Choi, Dong-Ju Yoo, Byung-Su Int J Heart Fail Trial Design Several surrogate biomarkers possess prognostic significance for heart failure (HF), and a decline in their respective values may predict clinical improvement. However, data on the prognostic value of these biomarkers during short-term follow-up after discharge in acute decompensated HF are scarce. We aim to evaluate the prognostic value of short-term follow-up of surrogate biomarkers for predicting the prognosis of hospitalized patients with acute decompensated HF. This multi-center, prospective study will enroll consecutive hospitalized patients with acute decompensated HF. All patients will undergo sampling and comparison of biomarkers, including plasma N-terminal pro-brain natriuretic peptide, growth differentiation factor 15, troponin-T, high-sensitivity C-reactive protein, and urinary albumin/creatinine ratio obtained within 1 month and 6 months after discharge from the index admission. The primary endpoint is a composite of cardiovascular mortality or HF hospitalization during 1 year of follow-up. We will investigate the prognostic value of multiple biomarkers for the primary endpoint. This trial will provide robust evidence for novel multi-biomarker strategies for acute decompensated HF in real-world settings. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04437628 Korean Society of Heart Failure 2022-04-04 /pmc/articles/PMC9383348/ /pubmed/36263107 http://dx.doi.org/10.36628/ijhf.2022.0005 Text en Copyright © 2022. Korean Society of Heart Failure https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Trial Design Cho, Dong-Hyuk Son, Jung-Woo Lee, Chan Joo Choi, Jimi Kim, Mi-Na Lee, Ju-Hee Lee, Sunki Yang, Dong Heon Cho, Hyun-Jai Choi, Jin-Oh Kim, Eung Ju Choi, Dong-Ju Yoo, Byung-Su Prognostic Value of Short-Term Follow-up of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design |
title | Prognostic Value of Short-Term Follow-up of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design |
title_full | Prognostic Value of Short-Term Follow-up of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design |
title_fullStr | Prognostic Value of Short-Term Follow-up of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design |
title_full_unstemmed | Prognostic Value of Short-Term Follow-up of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design |
title_short | Prognostic Value of Short-Term Follow-up of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design |
title_sort | prognostic value of short-term follow-up of multiple biomarkers after discharge in hospitalized patients with acute heart failure (postbio-hf): rationale and study design |
topic | Trial Design |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9383348/ https://www.ncbi.nlm.nih.gov/pubmed/36263107 http://dx.doi.org/10.36628/ijhf.2022.0005 |
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