Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers

The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2–specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Sablerolles, Roos S G, Rietdijk, Wim J R, Goorhuis, Abraham, Postma, Douwe F, Visser, Leo G, Schmitz, Katharina S, Geers, Daryl, Bogers, Susanne, van Haren, Eva, Koopmans, Marion P G, Dalm, Virgil A S H, Kootstra, Neeltje A, Huckriede, Anke L W, Akkerman, Renate, Beukema, Martin, Lafeber, Melvin, van Baarle, Debbie, de Vries, Rory D, van der Kuy, P Hugo M, GeurtsvanKessel, Corine H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384313/
https://www.ncbi.nlm.nih.gov/pubmed/35723273
http://dx.doi.org/10.1093/cid/ciac495
_version_ 1784769429727346688
author Sablerolles, Roos S G
Rietdijk, Wim J R
Goorhuis, Abraham
Postma, Douwe F
Visser, Leo G
Schmitz, Katharina S
Geers, Daryl
Bogers, Susanne
van Haren, Eva
Koopmans, Marion P G
Dalm, Virgil A S H
Kootstra, Neeltje A
Huckriede, Anke L W
Akkerman, Renate
Beukema, Martin
Lafeber, Melvin
van Baarle, Debbie
de Vries, Rory D
van der Kuy, P Hugo M
GeurtsvanKessel, Corine H
author_facet Sablerolles, Roos S G
Rietdijk, Wim J R
Goorhuis, Abraham
Postma, Douwe F
Visser, Leo G
Schmitz, Katharina S
Geers, Daryl
Bogers, Susanne
van Haren, Eva
Koopmans, Marion P G
Dalm, Virgil A S H
Kootstra, Neeltje A
Huckriede, Anke L W
Akkerman, Renate
Beukema, Martin
Lafeber, Melvin
van Baarle, Debbie
de Vries, Rory D
van der Kuy, P Hugo M
GeurtsvanKessel, Corine H
author_sort Sablerolles, Roos S G
collection PubMed
description The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2–specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.
format Online
Article
Text
id pubmed-9384313
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-93843132022-08-18 Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers Sablerolles, Roos S G Rietdijk, Wim J R Goorhuis, Abraham Postma, Douwe F Visser, Leo G Schmitz, Katharina S Geers, Daryl Bogers, Susanne van Haren, Eva Koopmans, Marion P G Dalm, Virgil A S H Kootstra, Neeltje A Huckriede, Anke L W Akkerman, Renate Beukema, Martin Lafeber, Melvin van Baarle, Debbie de Vries, Rory D van der Kuy, P Hugo M GeurtsvanKessel, Corine H Clin Infect Dis Brief Report The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2–specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed. Oxford University Press 2022-07-15 /pmc/articles/PMC9384313/ /pubmed/35723273 http://dx.doi.org/10.1093/cid/ciac495 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Sablerolles, Roos S G
Rietdijk, Wim J R
Goorhuis, Abraham
Postma, Douwe F
Visser, Leo G
Schmitz, Katharina S
Geers, Daryl
Bogers, Susanne
van Haren, Eva
Koopmans, Marion P G
Dalm, Virgil A S H
Kootstra, Neeltje A
Huckriede, Anke L W
Akkerman, Renate
Beukema, Martin
Lafeber, Melvin
van Baarle, Debbie
de Vries, Rory D
van der Kuy, P Hugo M
GeurtsvanKessel, Corine H
Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers
title Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers
title_full Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers
title_fullStr Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers
title_full_unstemmed Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers
title_short Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers
title_sort durability of immune responses after boosting in ad26.cov2.s-primed healthcare workers
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384313/
https://www.ncbi.nlm.nih.gov/pubmed/35723273
http://dx.doi.org/10.1093/cid/ciac495
work_keys_str_mv AT sablerollesroossg durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT rietdijkwimjr durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT goorhuisabraham durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT postmadouwef durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT visserleog durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT schmitzkatharinas durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT geersdaryl durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT bogerssusanne durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT vanhareneva durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT koopmansmarionpg durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT dalmvirgilash durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT kootstraneeltjea durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT huckriedeankelw durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT akkermanrenate durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT beukemamartin durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT lafebermelvin durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT vanbaarledebbie durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT devriesroryd durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT vanderkuyphugom durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT geurtsvankesselcorineh durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers
AT durabilityofimmuneresponsesafterboostinginad26cov2sprimedhealthcareworkers

Ejemplares similares