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Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status

The emergence and global dissemination of Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) variants of concern (VOCs) have been described as the main factor driving the Coronavirus Disease 2019 pandemic. In Brazil, the Gamma variant dominated the epidemiological scenario during the first perio...

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Autores principales: Fonseca, Paula L C, Moreira, Filipe R R, de Souza, Rafael M, Guimarães, Natália R, Carvalho, Nara O, Adelino, Talita E R, Alves, Hugo J, Alvim, Luige B, Candido, Darlan S, Coelho, Helena P, Costa, Alana V B, Costa, Walyson C, de Carvalho, Alex F, de Faria, Bruna W F, de Lima, Aline B, de Oliveira, Eneida S, de Souza, Carolina S A, de Souza, Fernanda G, Dias, Rillery C, Geddes, Victor E V, Godinho, Igor P, Gonçalves, Alessandro L, Lourenço, Karine L, Magalhães, Rubens D M, Malta, Frederico S V, Medeiros, Eva L A, Mendes, Fernanda S, Mendes, Pedro H B de P, Mendonça, Cristiane P T B, Menezes, Andre L, Menezes, Diego, Menezes, Mariane T, Miguita, Lucyene, Moreira, Rennan G, Peixoto, Renata B, Queiroz, Daniel C, Ribeiro, Adriana A, Ribeiro, Ana Paula de B, Saliba, Juliana W, Sato, Hugo I, Silva, Joice do P, Silva, Natiely P, Faria, Nuno R, Teixeira, Santuza M R, da Fonseca, Flávio G, Fernandes, Ana Paula S M, Zauli, Danielle A G, Januario, José Nélio, de Oliveira, Jaqueline S, Iani, Felipe C de M, de Aguiar, Renato S, de Souza, Renan P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384558/
https://www.ncbi.nlm.nih.gov/pubmed/35996592
http://dx.doi.org/10.1093/ve/veac064
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author Fonseca, Paula L C
Moreira, Filipe R R
de Souza, Rafael M
Guimarães, Natália R
Carvalho, Nara O
Adelino, Talita E R
Alves, Hugo J
Alvim, Luige B
Candido, Darlan S
Coelho, Helena P
Costa, Alana V B
Costa, Walyson C
de Carvalho, Alex F
de Faria, Bruna W F
de Lima, Aline B
de Oliveira, Eneida S
de Souza, Carolina S A
de Souza, Fernanda G
Dias, Rillery C
Geddes, Victor E V
Godinho, Igor P
Gonçalves, Alessandro L
Lourenço, Karine L
Magalhães, Rubens D M
Malta, Frederico S V
Medeiros, Eva L A
Mendes, Fernanda S
Mendes, Pedro H B de P
Mendonça, Cristiane P T B
Menezes, Andre L
Menezes, Diego
Menezes, Mariane T
Miguita, Lucyene
Moreira, Rennan G
Peixoto, Renata B
Queiroz, Daniel C
Ribeiro, Adriana A
Ribeiro, Ana Paula de B
Saliba, Juliana W
Sato, Hugo I
Silva, Joice do P
Silva, Natiely P
Faria, Nuno R
Teixeira, Santuza M R
da Fonseca, Flávio G
Fernandes, Ana Paula S M
Zauli, Danielle A G
Januario, José Nélio
de Oliveira, Jaqueline S
Iani, Felipe C de M
de Aguiar, Renato S
de Souza, Renan P
author_facet Fonseca, Paula L C
Moreira, Filipe R R
de Souza, Rafael M
Guimarães, Natália R
Carvalho, Nara O
Adelino, Talita E R
Alves, Hugo J
Alvim, Luige B
Candido, Darlan S
Coelho, Helena P
Costa, Alana V B
Costa, Walyson C
de Carvalho, Alex F
de Faria, Bruna W F
de Lima, Aline B
de Oliveira, Eneida S
de Souza, Carolina S A
de Souza, Fernanda G
Dias, Rillery C
Geddes, Victor E V
Godinho, Igor P
Gonçalves, Alessandro L
Lourenço, Karine L
Magalhães, Rubens D M
Malta, Frederico S V
Medeiros, Eva L A
Mendes, Fernanda S
Mendes, Pedro H B de P
Mendonça, Cristiane P T B
Menezes, Andre L
Menezes, Diego
Menezes, Mariane T
Miguita, Lucyene
Moreira, Rennan G
Peixoto, Renata B
Queiroz, Daniel C
Ribeiro, Adriana A
Ribeiro, Ana Paula de B
Saliba, Juliana W
Sato, Hugo I
Silva, Joice do P
Silva, Natiely P
Faria, Nuno R
Teixeira, Santuza M R
da Fonseca, Flávio G
Fernandes, Ana Paula S M
Zauli, Danielle A G
Januario, José Nélio
de Oliveira, Jaqueline S
Iani, Felipe C de M
de Aguiar, Renato S
de Souza, Renan P
author_sort Fonseca, Paula L C
collection PubMed
description The emergence and global dissemination of Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) variants of concern (VOCs) have been described as the main factor driving the Coronavirus Disease 2019 pandemic. In Brazil, the Gamma variant dominated the epidemiological scenario during the first period of 2021. Many Brazilian regions detected the Delta variant after its first description and documented its spread. To monitor the introduction and spread of VOC Delta, we performed Polymerase Chain Reaction (PCR) genotyping and genome sequencing in ten regional sentinel units from June to October 2021 in the State of Minas Gerais (MG). We documented the introduction and spread of Delta, comprising 70 per cent of the cases 8 weeks later. Comparing the viral loads of the Gamma and Delta dominance periods, we provide additional evidence that the latter is more transmissible. The spread and dominance of Delta did not culminate in the increase in cases and deaths, suggesting that the vaccination may have restrained the epidemic growth. Analysis of 224 novel Delta genomes revealed that Rio de Janeiro state was the primary source for disseminating this variant in the state of MG. We present the establishment of Delta, providing evidence of its enhanced transmissibility and showing that this variant shift did not aggravate the epidemiological scenario in a high immunity setting.
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spelling pubmed-93845582022-08-18 Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status Fonseca, Paula L C Moreira, Filipe R R de Souza, Rafael M Guimarães, Natália R Carvalho, Nara O Adelino, Talita E R Alves, Hugo J Alvim, Luige B Candido, Darlan S Coelho, Helena P Costa, Alana V B Costa, Walyson C de Carvalho, Alex F de Faria, Bruna W F de Lima, Aline B de Oliveira, Eneida S de Souza, Carolina S A de Souza, Fernanda G Dias, Rillery C Geddes, Victor E V Godinho, Igor P Gonçalves, Alessandro L Lourenço, Karine L Magalhães, Rubens D M Malta, Frederico S V Medeiros, Eva L A Mendes, Fernanda S Mendes, Pedro H B de P Mendonça, Cristiane P T B Menezes, Andre L Menezes, Diego Menezes, Mariane T Miguita, Lucyene Moreira, Rennan G Peixoto, Renata B Queiroz, Daniel C Ribeiro, Adriana A Ribeiro, Ana Paula de B Saliba, Juliana W Sato, Hugo I Silva, Joice do P Silva, Natiely P Faria, Nuno R Teixeira, Santuza M R da Fonseca, Flávio G Fernandes, Ana Paula S M Zauli, Danielle A G Januario, José Nélio de Oliveira, Jaqueline S Iani, Felipe C de M de Aguiar, Renato S de Souza, Renan P Virus Evol Research Article The emergence and global dissemination of Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) variants of concern (VOCs) have been described as the main factor driving the Coronavirus Disease 2019 pandemic. In Brazil, the Gamma variant dominated the epidemiological scenario during the first period of 2021. Many Brazilian regions detected the Delta variant after its first description and documented its spread. To monitor the introduction and spread of VOC Delta, we performed Polymerase Chain Reaction (PCR) genotyping and genome sequencing in ten regional sentinel units from June to October 2021 in the State of Minas Gerais (MG). We documented the introduction and spread of Delta, comprising 70 per cent of the cases 8 weeks later. Comparing the viral loads of the Gamma and Delta dominance periods, we provide additional evidence that the latter is more transmissible. The spread and dominance of Delta did not culminate in the increase in cases and deaths, suggesting that the vaccination may have restrained the epidemic growth. Analysis of 224 novel Delta genomes revealed that Rio de Janeiro state was the primary source for disseminating this variant in the state of MG. We present the establishment of Delta, providing evidence of its enhanced transmissibility and showing that this variant shift did not aggravate the epidemiological scenario in a high immunity setting. Oxford University Press 2022-07-27 /pmc/articles/PMC9384558/ /pubmed/35996592 http://dx.doi.org/10.1093/ve/veac064 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Research Article
Fonseca, Paula L C
Moreira, Filipe R R
de Souza, Rafael M
Guimarães, Natália R
Carvalho, Nara O
Adelino, Talita E R
Alves, Hugo J
Alvim, Luige B
Candido, Darlan S
Coelho, Helena P
Costa, Alana V B
Costa, Walyson C
de Carvalho, Alex F
de Faria, Bruna W F
de Lima, Aline B
de Oliveira, Eneida S
de Souza, Carolina S A
de Souza, Fernanda G
Dias, Rillery C
Geddes, Victor E V
Godinho, Igor P
Gonçalves, Alessandro L
Lourenço, Karine L
Magalhães, Rubens D M
Malta, Frederico S V
Medeiros, Eva L A
Mendes, Fernanda S
Mendes, Pedro H B de P
Mendonça, Cristiane P T B
Menezes, Andre L
Menezes, Diego
Menezes, Mariane T
Miguita, Lucyene
Moreira, Rennan G
Peixoto, Renata B
Queiroz, Daniel C
Ribeiro, Adriana A
Ribeiro, Ana Paula de B
Saliba, Juliana W
Sato, Hugo I
Silva, Joice do P
Silva, Natiely P
Faria, Nuno R
Teixeira, Santuza M R
da Fonseca, Flávio G
Fernandes, Ana Paula S M
Zauli, Danielle A G
Januario, José Nélio
de Oliveira, Jaqueline S
Iani, Felipe C de M
de Aguiar, Renato S
de Souza, Renan P
Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status
title Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status
title_full Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status
title_fullStr Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status
title_full_unstemmed Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status
title_short Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status
title_sort tracking the turnover of sars-cov-2 vocs gamma to delta in a brazilian state (minas gerais) with a high-vaccination status
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384558/
https://www.ncbi.nlm.nih.gov/pubmed/35996592
http://dx.doi.org/10.1093/ve/veac064
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