Clinical Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 Rapid Antigen Tests During the Omicron Wave in South Africa( )

We evaluated the performance of nasal and nasopharyngeal Standard Q COVID-19 [coronavirus disease 2019] Ag tests (SD Biosensor) and the Panbio COVID-19 Ag Rapid Test Device (nasal; Abbott) against the Abbott RealTime severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assay during the Omicr...

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Autores principales: Samsunder, Natasha, de Vos, Margaretha, Ngcapu, Sinaye, Giandhari, Jennifer, Lewis, Lara, Kharsany, Ayesha B M, Cawood, Cherie, de Oliveira, Tulio, Karim, Quarraisha Abdool, Karim, Salim Abdool, Naidoo, Kogieleum, Escadafal, Camille, Sivro, Aida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384653/
https://www.ncbi.nlm.nih.gov/pubmed/35921539
http://dx.doi.org/10.1093/infdis/jiac333
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author Samsunder, Natasha
de Vos, Margaretha
Ngcapu, Sinaye
Giandhari, Jennifer
Lewis, Lara
Kharsany, Ayesha B M
Cawood, Cherie
de Oliveira, Tulio
Karim, Quarraisha Abdool
Karim, Salim Abdool
Naidoo, Kogieleum
Escadafal, Camille
Sivro, Aida
author_facet Samsunder, Natasha
de Vos, Margaretha
Ngcapu, Sinaye
Giandhari, Jennifer
Lewis, Lara
Kharsany, Ayesha B M
Cawood, Cherie
de Oliveira, Tulio
Karim, Quarraisha Abdool
Karim, Salim Abdool
Naidoo, Kogieleum
Escadafal, Camille
Sivro, Aida
author_sort Samsunder, Natasha
collection PubMed
description We evaluated the performance of nasal and nasopharyngeal Standard Q COVID-19 [coronavirus disease 2019] Ag tests (SD Biosensor) and the Panbio COVID-19 Ag Rapid Test Device (nasal; Abbott) against the Abbott RealTime severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assay during the Omicron (clades 21M, 21K, and 21L) wave in South Africa. Overall, all evaluated tests performed well, with high sensitivity (range, 77.78%–81.42%) and excellent specificity values (>99%). The sensitivity of rapid antigen tests increased above 90% in samples with cycle threshold <20, and all 3 tests performed best within the first week after symptom onset.
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spelling pubmed-93846532022-08-18 Clinical Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 Rapid Antigen Tests During the Omicron Wave in South Africa( ) Samsunder, Natasha de Vos, Margaretha Ngcapu, Sinaye Giandhari, Jennifer Lewis, Lara Kharsany, Ayesha B M Cawood, Cherie de Oliveira, Tulio Karim, Quarraisha Abdool Karim, Salim Abdool Naidoo, Kogieleum Escadafal, Camille Sivro, Aida J Infect Dis Brief Report We evaluated the performance of nasal and nasopharyngeal Standard Q COVID-19 [coronavirus disease 2019] Ag tests (SD Biosensor) and the Panbio COVID-19 Ag Rapid Test Device (nasal; Abbott) against the Abbott RealTime severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assay during the Omicron (clades 21M, 21K, and 21L) wave in South Africa. Overall, all evaluated tests performed well, with high sensitivity (range, 77.78%–81.42%) and excellent specificity values (>99%). The sensitivity of rapid antigen tests increased above 90% in samples with cycle threshold <20, and all 3 tests performed best within the first week after symptom onset. Oxford University Press 2022-08-03 /pmc/articles/PMC9384653/ /pubmed/35921539 http://dx.doi.org/10.1093/infdis/jiac333 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Samsunder, Natasha
de Vos, Margaretha
Ngcapu, Sinaye
Giandhari, Jennifer
Lewis, Lara
Kharsany, Ayesha B M
Cawood, Cherie
de Oliveira, Tulio
Karim, Quarraisha Abdool
Karim, Salim Abdool
Naidoo, Kogieleum
Escadafal, Camille
Sivro, Aida
Clinical Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 Rapid Antigen Tests During the Omicron Wave in South Africa( )
title Clinical Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 Rapid Antigen Tests During the Omicron Wave in South Africa( )
title_full Clinical Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 Rapid Antigen Tests During the Omicron Wave in South Africa( )
title_fullStr Clinical Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 Rapid Antigen Tests During the Omicron Wave in South Africa( )
title_full_unstemmed Clinical Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 Rapid Antigen Tests During the Omicron Wave in South Africa( )
title_short Clinical Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 Rapid Antigen Tests During the Omicron Wave in South Africa( )
title_sort clinical evaluation of severe acute respiratory syndrome coronavirus 2 rapid antigen tests during the omicron wave in south africa( )
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384653/
https://www.ncbi.nlm.nih.gov/pubmed/35921539
http://dx.doi.org/10.1093/infdis/jiac333
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