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B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity

Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver disease, and cancer. It is also linked with more severe complications from infections, including COVID-19, and poor vaccine responses. Chronic, low-grade inflammation and associated immune perturbations play...

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Autores principales: Oleinika, Kristine, Slisere, Baiba, Catalán, Diego, Rosser, Elizabeth C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384752/
https://www.ncbi.nlm.nih.gov/pubmed/35960996
http://dx.doi.org/10.1093/cei/uxac079
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author Oleinika, Kristine
Slisere, Baiba
Catalán, Diego
Rosser, Elizabeth C
author_facet Oleinika, Kristine
Slisere, Baiba
Catalán, Diego
Rosser, Elizabeth C
author_sort Oleinika, Kristine
collection PubMed
description Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver disease, and cancer. It is also linked with more severe complications from infections, including COVID-19, and poor vaccine responses. Chronic, low-grade inflammation and associated immune perturbations play an important role in determining morbidity in people living with obesity. The contribution of B cells to immune dysregulation and meta-inflammation associated with obesity has been documented by studies over the past decade. With a focus on human studies, here we consolidate the observations demonstrating that there is altered B cell subset composition, differentiation, and function both systemically and in the adipose tissue of individuals living with obesity. Finally, we discuss the potential factors that drive B cell dysfunction in obesity and propose a model by which altered B cell subset composition in obesity underlies dysfunctional B cell responses to novel pathogens.
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spelling pubmed-93847522022-08-18 B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity Oleinika, Kristine Slisere, Baiba Catalán, Diego Rosser, Elizabeth C Clin Exp Immunol Review Series: Human B Cells (Series Editors: Jo Spencer, Mats Bemark, Thomas J. Tull) Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver disease, and cancer. It is also linked with more severe complications from infections, including COVID-19, and poor vaccine responses. Chronic, low-grade inflammation and associated immune perturbations play an important role in determining morbidity in people living with obesity. The contribution of B cells to immune dysregulation and meta-inflammation associated with obesity has been documented by studies over the past decade. With a focus on human studies, here we consolidate the observations demonstrating that there is altered B cell subset composition, differentiation, and function both systemically and in the adipose tissue of individuals living with obesity. Finally, we discuss the potential factors that drive B cell dysfunction in obesity and propose a model by which altered B cell subset composition in obesity underlies dysfunctional B cell responses to novel pathogens. Oxford University Press 2022-08-12 /pmc/articles/PMC9384752/ /pubmed/35960996 http://dx.doi.org/10.1093/cei/uxac079 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Immunology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Series: Human B Cells (Series Editors: Jo Spencer, Mats Bemark, Thomas J. Tull)
Oleinika, Kristine
Slisere, Baiba
Catalán, Diego
Rosser, Elizabeth C
B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity
title B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity
title_full B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity
title_fullStr B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity
title_full_unstemmed B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity
title_short B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity
title_sort b cell contribution to immunometabolic dysfunction and impaired immune responses in obesity
topic Review Series: Human B Cells (Series Editors: Jo Spencer, Mats Bemark, Thomas J. Tull)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384752/
https://www.ncbi.nlm.nih.gov/pubmed/35960996
http://dx.doi.org/10.1093/cei/uxac079
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