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Cost-effectiveness of alternative minimum recall intervals between whole blood donations

BACKGROUND: The INTERVAL trial showed shorter inter-donation intervals could safely increase the frequency of whole-blood donation. We extended the INTERVAL trial to consider the relative cost-effectiveness of reduced inter-donation intervals. METHODS: Our within-trial cost-effectiveness analysis (C...

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Autores principales: Sadique, Zia, Willis, Sarah, Corte, Kaat De, Pennington, Mark, Moore, Carmel, Kaptoge, Stephen, Angelantonio, Emanuele Di, Miflin, Gail, Roberts, David J., Grieve, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384981/
https://www.ncbi.nlm.nih.gov/pubmed/35976959
http://dx.doi.org/10.1371/journal.pone.0272854
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author Sadique, Zia
Willis, Sarah
Corte, Kaat De
Pennington, Mark
Moore, Carmel
Kaptoge, Stephen
Angelantonio, Emanuele Di
Miflin, Gail
Roberts, David J.
Grieve, Richard
author_facet Sadique, Zia
Willis, Sarah
Corte, Kaat De
Pennington, Mark
Moore, Carmel
Kaptoge, Stephen
Angelantonio, Emanuele Di
Miflin, Gail
Roberts, David J.
Grieve, Richard
author_sort Sadique, Zia
collection PubMed
description BACKGROUND: The INTERVAL trial showed shorter inter-donation intervals could safely increase the frequency of whole-blood donation. We extended the INTERVAL trial to consider the relative cost-effectiveness of reduced inter-donation intervals. METHODS: Our within-trial cost-effectiveness analysis (CEA) used data from 44,863 whole-blood donors randomly assigned to 12, 10 or 8 week (males), and 16, 14 or 12 week inter-donation intervals (females). The CEA analysed the number of whole-blood donations, deferrals including low- haemoglobin deferrals, and donors’ health-related quality of life (QoL) to report costs and cost-effectiveness over two years. FINDINGS: The mean number of blood donation visits over two years was higher for the reduced interval strategies, for males (7.76, 6.60 and 5.68 average donations in the 8-, 10- and 12- week arms) and for females (5.10, 4.60 and 4.01 donations in the 12-, 14- and 16- week arms). For males, the average rate of deferral for low haemoglobin per session attended, was 5.71% (8- week arm), 3.73% (10- week), and 2.55% (12- week), and for females the rates were: 7.92% (12-week), 6.63% (14- week), and 5.05% (16- week). Donors’ QoL was similar across strategies, although self-reported symptoms were increased with shorter donation intervals. The shorter interval strategies increased average cost, with incremental cost-effectiveness ratios of £9.51 (95% CI 9.33 to 9.69) per additional whole-blood donation for the 8- versus 12- week interval for males, and £10.17 (95% CI 9.80 to 10.54) for the 12- versus 16- week interval arm for females. CONCLUSIONS: Over two years, reducing the minimum donation interval could provide additional units of whole-blood at a small additional cost, including for those donor subgroups whose blood type is in relatively high demand. However, the significance of self-reported symptoms needs to be investigated further before these policies are expanded.
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spelling pubmed-93849812022-08-18 Cost-effectiveness of alternative minimum recall intervals between whole blood donations Sadique, Zia Willis, Sarah Corte, Kaat De Pennington, Mark Moore, Carmel Kaptoge, Stephen Angelantonio, Emanuele Di Miflin, Gail Roberts, David J. Grieve, Richard PLoS One Research Article BACKGROUND: The INTERVAL trial showed shorter inter-donation intervals could safely increase the frequency of whole-blood donation. We extended the INTERVAL trial to consider the relative cost-effectiveness of reduced inter-donation intervals. METHODS: Our within-trial cost-effectiveness analysis (CEA) used data from 44,863 whole-blood donors randomly assigned to 12, 10 or 8 week (males), and 16, 14 or 12 week inter-donation intervals (females). The CEA analysed the number of whole-blood donations, deferrals including low- haemoglobin deferrals, and donors’ health-related quality of life (QoL) to report costs and cost-effectiveness over two years. FINDINGS: The mean number of blood donation visits over two years was higher for the reduced interval strategies, for males (7.76, 6.60 and 5.68 average donations in the 8-, 10- and 12- week arms) and for females (5.10, 4.60 and 4.01 donations in the 12-, 14- and 16- week arms). For males, the average rate of deferral for low haemoglobin per session attended, was 5.71% (8- week arm), 3.73% (10- week), and 2.55% (12- week), and for females the rates were: 7.92% (12-week), 6.63% (14- week), and 5.05% (16- week). Donors’ QoL was similar across strategies, although self-reported symptoms were increased with shorter donation intervals. The shorter interval strategies increased average cost, with incremental cost-effectiveness ratios of £9.51 (95% CI 9.33 to 9.69) per additional whole-blood donation for the 8- versus 12- week interval for males, and £10.17 (95% CI 9.80 to 10.54) for the 12- versus 16- week interval arm for females. CONCLUSIONS: Over two years, reducing the minimum donation interval could provide additional units of whole-blood at a small additional cost, including for those donor subgroups whose blood type is in relatively high demand. However, the significance of self-reported symptoms needs to be investigated further before these policies are expanded. Public Library of Science 2022-08-17 /pmc/articles/PMC9384981/ /pubmed/35976959 http://dx.doi.org/10.1371/journal.pone.0272854 Text en © 2022 Sadique et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sadique, Zia
Willis, Sarah
Corte, Kaat De
Pennington, Mark
Moore, Carmel
Kaptoge, Stephen
Angelantonio, Emanuele Di
Miflin, Gail
Roberts, David J.
Grieve, Richard
Cost-effectiveness of alternative minimum recall intervals between whole blood donations
title Cost-effectiveness of alternative minimum recall intervals between whole blood donations
title_full Cost-effectiveness of alternative minimum recall intervals between whole blood donations
title_fullStr Cost-effectiveness of alternative minimum recall intervals between whole blood donations
title_full_unstemmed Cost-effectiveness of alternative minimum recall intervals between whole blood donations
title_short Cost-effectiveness of alternative minimum recall intervals between whole blood donations
title_sort cost-effectiveness of alternative minimum recall intervals between whole blood donations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384981/
https://www.ncbi.nlm.nih.gov/pubmed/35976959
http://dx.doi.org/10.1371/journal.pone.0272854
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